TY - JOUR
T1 - Serum cystatin C level is associated with carotid arterial wall elasticity in subjects with type 2 diabetes mellitus
T2 - A potential marker of early-stage atherosclerosis
AU - Kaneko, Rei
AU - Sawada, Shojiro
AU - Tokita, Ai
AU - Honkura, Rieko
AU - Tamura, Noriko
AU - Kodama, Shinjiro
AU - Izumi, Tomohito
AU - Takahashi, Kei
AU - Uno, Kenji
AU - Imai, Junta
AU - Yamada, Tetsuya
AU - Miyachi, Yukiya
AU - Hasegawa, Hideyuki
AU - Kanai, Hiroshi
AU - Ishigaki, Yasushi
AU - Katagiri, Hideki
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research ( 16 K09773 and 15 K09416 ) to S. Sawada and Y. Ishigaki, respectively, from Japan Society for the Promotion of Science – Japan.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/5
Y1 - 2018/5
N2 - Aims: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. Methods: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria. We measured serum cystatin C, the estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), and analyzed the associations between these markers and arterial wall elasticity (Eθ), IMT and the cardio-ankle velocity index. Results: Multiple linear regression analyses revealed that cystatin C was significantly associated with Eθ, while neither eGFR nor ACR showed an association. Furthermore, among the examined atherosclerotic markers, Eθ was most reliably associated with cystatin C. Additionally, the association between cystatin C and Eθ disappeared in the low elasticity subgroup, which included subjects in whom no atherosclerotic changes had yet been initiated. Conclusions: In T2DM patients without apparent arterial wall thickening, cystatin C is strongly and independently associated with arterial wall elasticity, which reflects the degree of subclinical atherosclerosis. Thus, cystatin C is a potentially useful marker of early-stage atherosclerosis.
AB - Aims: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. Methods: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria. We measured serum cystatin C, the estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), and analyzed the associations between these markers and arterial wall elasticity (Eθ), IMT and the cardio-ankle velocity index. Results: Multiple linear regression analyses revealed that cystatin C was significantly associated with Eθ, while neither eGFR nor ACR showed an association. Furthermore, among the examined atherosclerotic markers, Eθ was most reliably associated with cystatin C. Additionally, the association between cystatin C and Eθ disappeared in the low elasticity subgroup, which included subjects in whom no atherosclerotic changes had yet been initiated. Conclusions: In T2DM patients without apparent arterial wall thickening, cystatin C is strongly and independently associated with arterial wall elasticity, which reflects the degree of subclinical atherosclerosis. Thus, cystatin C is a potentially useful marker of early-stage atherosclerosis.
KW - Arterial wall elasticity
KW - Cystatin C
KW - Early-stage atherosclerosis
KW - Type 2 diabetes mellitus
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U2 - 10.1016/j.diabres.2018.02.003
DO - 10.1016/j.diabres.2018.02.003
M3 - Article
C2 - 29453992
AN - SCOPUS:85042906817
SN - 0168-8227
VL - 139
SP - 43
EP - 51
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -
