Serum levels of angiopoietin-2, but not angiopoietin-1, are elevated in patients with erythrodermic cutaneous T-cell lymphoma

Makiko Kawaguchi, Makoto Sugaya, Hiraku Suga, Tomomitsu Miyagaki, Hanako Ohmatsu, Hideki Fujita, Yoshi Hide Asano, Yayoi Tada, Takafumi Kadono, Shinichi Sato

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Angiogenesis is a crucial process in the growth and progression of cancer, correlating with the metastatic potential of tumour cells. Angiopoietins are ligands for the endothelium-specifc tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-1, Ang-2, Ang-3 and Ang-4. The roles of Ang-1 and Ang-2 have recently been clarifed as crucial in angiogenesis. In this report, we measured serum Ang-1 and Ang-2 levels in patients with cutaneous T-cell lymphoma (CTCL). Serum levels of Ang-2, but not Ang-1, in patients with Sézary syndrome were significantly higher than those in patch mycosis fungoides (MF), plaque/tumour MF, and healthy controls. In patients with CTCL, serum Ang-2 correlated with disease activity. Moreover, the numbers of Ang-2+ cells in lesional skin of CTCL were signifcantly larger than those in normal skin. These results suggest that Ang-2 may have important roles in the development of CTCL.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalActa Dermato-Venereologica
Volume94
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Angiopoietin-1
  • Angiopoietin-2
  • CCL26
  • CCL27
  • Cutaneous T-cell lympho-ma
  • Mycosis fungoides
  • Sézary syndrome

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