TY - JOUR
T1 - Serum levels of tissue factor pathway inhibitor
T2 - Potential association with Raynaud’s phenomenon and telangiectasia in patients with systemic sclerosis
AU - Norimatsu, Yuta
AU - Miyagawa, Takuya
AU - Fukui, Yuki
AU - Omatsu, Jun
AU - Toyama, Satoshi
AU - Awaji, Kentaro
AU - Ikawa, Tetsuya
AU - Watanabe, Yusuke
AU - Yoshizaki, Ayumi
AU - Sato, Shinichi
AU - Asano, Yoshihide
N1 - Funding Information:
This work was supported by a grant for Research on Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan. The funder was not involved in study design, data collection, data analysis, manuscript preparation, and publication decisions.
Publisher Copyright:
© 2021 Japanese Dermatological Association
PY - 2021/8
Y1 - 2021/8
N2 - Vasculopathy is a critical step of systemic sclerosis (SSc) development, bridging between autoimmune inflammation and tissue fibrosis. Impaired coagulation system is a part of SSc vasculopathy, but the role of tissue factor pathway inhibitor (TFPI), a critical regulator of the extrinsic coagulation pathway, remained unknown. Therefore, we evaluated the clinical correlation of serum TFPI levels in SSc patients. Serum TFPI levels were comparable between SSc and control participants, but SSc patients with Raynaud’s phenomenon and telangiectasia had significantly lower serum TFPI levels than those without. Importantly, there was a significant positive correlation between serum TFPI levels and protein S activity. These results support the critical role of impaired coagulation system in SSc.
AB - Vasculopathy is a critical step of systemic sclerosis (SSc) development, bridging between autoimmune inflammation and tissue fibrosis. Impaired coagulation system is a part of SSc vasculopathy, but the role of tissue factor pathway inhibitor (TFPI), a critical regulator of the extrinsic coagulation pathway, remained unknown. Therefore, we evaluated the clinical correlation of serum TFPI levels in SSc patients. Serum TFPI levels were comparable between SSc and control participants, but SSc patients with Raynaud’s phenomenon and telangiectasia had significantly lower serum TFPI levels than those without. Importantly, there was a significant positive correlation between serum TFPI levels and protein S activity. These results support the critical role of impaired coagulation system in SSc.
KW - coagulation
KW - Raynaud’s phenomenon
KW - systemic sclerosis
KW - telangiectasia
KW - tissue factor pathway inhibitor
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U2 - 10.1111/1346-8138.15893
DO - 10.1111/1346-8138.15893
M3 - Article
C2 - 33848376
AN - SCOPUS:85104264812
SN - 0385-2407
VL - 48
SP - 1253
EP - 1256
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 8
ER -