TY - JOUR
T1 - Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma
AU - Suga, Hiraku
AU - Sugaya, Makoto
AU - Miyagaki, Tomomitsu
AU - Kawaguchi, Makiko
AU - Morimura, Sohshi
AU - Kai, Hiromichi
AU - Kagami, Shinji
AU - Ohmatsu, Hanako
AU - Fujita, Hideki
AU - Asano, Yoshihide
AU - Tada, Yayoi
AU - Kadono, Takafumi
AU - Sato, Shinichi
PY - 2013/9
Y1 - 2013/9
N2 - Visfatin, a novel adipocytokine, is related with chronic inflammatory diseases, especially those characterized by T helper (Th)1-type immune responses. In this study, we examined serum visfatin levels in patients with atopic dermatitis (AD) or cutaneous T-cell lymphoma (CTCL), both of which are Th2-dominant diseases. Serum visfatin levels in patients with AD or advanced stage CTCL were significantly elevated compared to healthy controls. In CTCL patients, serum visfatin levels significantly decreased after treatment. Serum visfatin levels correlated with eosinophil counts inADpatients, whereas they correlated with the visual analogue scale itch scores and serum C-C motif ligand (CCL) 11 and CCL26 levels in CTCL patients. Visfatin expression by adipose tissue in lesional skin of AD and advanced stage CTCL was enhanced compared to that of healthy controls. These results suggest that visfatin may also be important in the development of Th2-dominant diseases as well as in Th1-type diseases.
AB - Visfatin, a novel adipocytokine, is related with chronic inflammatory diseases, especially those characterized by T helper (Th)1-type immune responses. In this study, we examined serum visfatin levels in patients with atopic dermatitis (AD) or cutaneous T-cell lymphoma (CTCL), both of which are Th2-dominant diseases. Serum visfatin levels in patients with AD or advanced stage CTCL were significantly elevated compared to healthy controls. In CTCL patients, serum visfatin levels significantly decreased after treatment. Serum visfatin levels correlated with eosinophil counts inADpatients, whereas they correlated with the visual analogue scale itch scores and serum C-C motif ligand (CCL) 11 and CCL26 levels in CTCL patients. Visfatin expression by adipose tissue in lesional skin of AD and advanced stage CTCL was enhanced compared to that of healthy controls. These results suggest that visfatin may also be important in the development of Th2-dominant diseases as well as in Th1-type diseases.
KW - Adipose tissue
KW - Atopic dermatitis
KW - Cutaneous T-cell lymphoma
KW - Mycosis fungoides
KW - Visfatin
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UR - http://www.scopus.com/inward/citedby.url?scp=84889056184&partnerID=8YFLogxK
U2 - 10.1684/ejd.2013.2107
DO - 10.1684/ejd.2013.2107
M3 - Article
C2 - 24001451
AN - SCOPUS:84889056184
SN - 1167-1122
VL - 23
SP - 629
EP - 635
JO - European Journal of Dermatology
JF - European Journal of Dermatology
IS - 5
ER -