TY - JOUR
T1 - Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4
AU - Kondo, Motonari
AU - Takeshita, Toshikazu
AU - Ishii, Naoto
AU - Nakamura, Masataka
AU - Watanabe, Sumiko
AU - Arai, Ken Ichi
AU - Sugamura, Kazuo
PY - 1993
Y1 - 1993
N2 - The γ chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the γ chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the γ chain cross-linked with IL-2, also immunoprecipitated the γ chain when cross-linked with IL-4. These results suggest that the IL-2 receptor γ chain is functionally involved in the IL-4 receptor complex.
AB - The γ chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the γ chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the γ chain cross-linked with IL-2, also immunoprecipitated the γ chain when cross-linked with IL-4. These results suggest that the IL-2 receptor γ chain is functionally involved in the IL-4 receptor complex.
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U2 - 10.1126/science.8266076
DO - 10.1126/science.8266076
M3 - Article
C2 - 8266076
AN - SCOPUS:0027731604
SN - 0036-8075
VL - 262
SP - 1874
EP - 1877
JO - Science
JF - Science
IS - 5141
ER -