Side effects of opioid and gene variants

Ichiro Sora, Hiroshi Komatsu, Moe Igari, Soichiro Ide, Kazutaka Ikeda, Naoto Shimoyama

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


There are individual differences in the analgesic effect and the side effect of the opioid to which genetic variation may be related. Analysis of μ-opioid receptor knockout mice indicated that inhibition of gastrointestinal transit by morphine is mediated by μ-opioid receptor. Our study suggested that gastrointestinal symptom (especially loss of appetite) as a side effect of opioid could be associated with the gene polymorphism of dopamine D2 receptor. Understanding of the relationships between gene polymorphisms and opioid sensitivities may lead to more-accurate prediction of the opioid sensitivity and opioid requirements in individual patients.

Original languageEnglish
Pages (from-to)1109-1111
Number of pages3
JournalJapanese Journal of Anesthesiology
Issue number9
Publication statusPublished - 2009 Sept


  • Constipation
  • Dopamine 2 receptor
  • Gastrointestinal symptoms
  • Nausea
  • μ-opioid receptor

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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