Abstract
There are individual differences in the analgesic effect and the side effect of the opioid to which genetic variation may be related. Analysis of μ-opioid receptor knockout mice indicated that inhibition of gastrointestinal transit by morphine is mediated by μ-opioid receptor. Our study suggested that gastrointestinal symptom (especially loss of appetite) as a side effect of opioid could be associated with the gene polymorphism of dopamine D2 receptor. Understanding of the relationships between gene polymorphisms and opioid sensitivities may lead to more-accurate prediction of the opioid sensitivity and opioid requirements in individual patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1109-1111 |
| Number of pages | 3 |
| Journal | Japanese Journal of Anesthesiology |
| Volume | 58 |
| Issue number | 9 |
| Publication status | Published - 2009 Sept |
Keywords
- Constipation
- Dopamine 2 receptor
- Gastrointestinal symptoms
- Nausea
- μ-opioid receptor
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine