TY - JOUR
T1 - Silica gel-assisted preparation of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions
AU - Mikami, Shinichi
AU - Tanaka, Hiroki
AU - Kishi, Hiroki
AU - Yoshida, Shuhei
AU - Toyota, Kozo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Six types of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions were prepared from the corresponding 2-(1-adamantylsulfanyl)-1,4-dihalo-3-(haloethynyl)benzene derivatives, by treatment with silica gel under thermal conditions. 4,7-Dihalobenzo[b]thiophenes, bearing two different halogen atoms (chlorine, bromine, or iodine), were also prepared from 2-(1-adamantylsulfanyl)-3-(ethynyl)-1,4-dihalobenzene derivatives.
AB - Six types of (bromo)(chloro)(iodo)benzo[b]thiophenes bearing halogen atoms at the 2-, 4-, and 7-positions were prepared from the corresponding 2-(1-adamantylsulfanyl)-1,4-dihalo-3-(haloethynyl)benzene derivatives, by treatment with silica gel under thermal conditions. 4,7-Dihalobenzo[b]thiophenes, bearing two different halogen atoms (chlorine, bromine, or iodine), were also prepared from 2-(1-adamantylsulfanyl)-3-(ethynyl)-1,4-dihalobenzene derivatives.
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U2 - 10.3987/COM-18-13937
DO - 10.3987/COM-18-13937
M3 - Article
AN - SCOPUS:85054029772
SN - 0385-5414
VL - 96
SP - 1529
EP - 1548
JO - Heterocycles
JF - Heterocycles
IS - 9
ER -