Simple automated preparation of O-[11C]methyl-L-tyrosine for routine clinical use

Yoichi Ishikawa; Ren Iwata; Shozo Furumoto; Claudio Pascali; Anna Bogni; Kazuo Kubota; Kiichi Ishiwata

doi:10.1016/j.apradiso.2005.01.014

Simple automated preparation of O-[¹¹C]methyl-L-tyrosine for routine clinical use

Yoichi Ishikawa, Ren Iwata, Shozo Furumoto, Claudio Pascali, Anna Bogni, Kazuo Kubota, Kiichi Ishiwata

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The previously reported preparation of O-[¹¹C]methyl-L-tyrosine ([¹¹C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [¹¹C]methyl iodide ([¹¹C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [ ¹¹C]MT was obtained within 30 min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [¹¹C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.

Original language	English
Pages (from-to)	55-61
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/j.apradiso.2005.01.014
Publication status	Published - 2005 Jul

Keywords

Amino acid transport
Automated synthesis
C-11
O-methyl-L-tyrosine
Tumor imaging

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2005.01.014

Cite this

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title = "Simple automated preparation of O-[11C]methyl-L-tyrosine for routine clinical use",

abstract = "The previously reported preparation of O-[11C]methyl-L-tyrosine ([11C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [11C]methyl iodide ([11C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [ 11C]MT was obtained within 30 min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [11C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.",

keywords = "Amino acid transport, Automated synthesis, C-11, O-methyl-L-tyrosine, Tumor imaging",

author = "Yoichi Ishikawa and Ren Iwata and Shozo Furumoto and Claudio Pascali and Anna Bogni and Kazuo Kubota and Kiichi Ishiwata",

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T1 - Simple automated preparation of O-[11C]methyl-L-tyrosine for routine clinical use

AU - Ishikawa, Yoichi

AU - Iwata, Ren

AU - Furumoto, Shozo

AU - Pascali, Claudio

AU - Bogni, Anna

AU - Kubota, Kazuo

AU - Ishiwata, Kiichi

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AB - The previously reported preparation of O-[11C]methyl-L-tyrosine ([11C]MT), a promising tumor imaging agent, has been now considerably simplified and automated. Main changes were the use of [11C]methyl iodide ([11C]MeI) in the reaction with l-tyrosine disodium and the use of solid phase extraction on commercially available cartridges instead of HPLC for the final purification. An injectable saline solution of [ 11C]MT was obtained within 30 min after EOB with radiochemical yield of ca. 60% (decay-corrected, based on [11C]MeI). Radiochemical purity was over 97%. The automated preparation was carried out using a miniature module employing manifold valves.

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