@article{4407a14845ff4d0ba10da7c0678ded97,
title = "Single-shot three-dimensional structure determination of nanocrystals with femtosecond X-ray free-electron laser pulses",
abstract = "Conventional three-dimensional (3D) structure determination methods require either multiple measurements at different sample orientations or a collection of serial sections through a sample. Here we report the experimental demonstration of single-shot 3D structure determination of an object; in this case, individual gold nanocrystals at ∼5.5{\^a} €‰nm resolution using ∼10{\^a} €‰fs X-ray free-electron laser pulses. Coherent diffraction patterns are collected from high-index-faceted nanocrystals, each struck by an X-ray free-electron laser pulse. Taking advantage of the symmetry of the nanocrystal and the curvature of the Ewald sphere, we reconstruct the 3D structure of each nanocrystal from a single-shot diffraction pattern. By averaging a sufficient number of identical nanocrystals, this method may be used to determine the 3D structure of nanocrystals at atomic resolution. As symmetry exists in many virus particles, this method may also be applied to 3D structure studies of such particles at nanometer resolution on femtosecond time scales.",
author = "Rui Xu and Huaidong Jiang and Changyong Song and Rodriguez, {Jose A.} and Zhifeng Huang and Chen, {Chien Chun} and Daewoong Nam and Jaehyun Park and Marcus Gallagher-Jones and Sangsoo Kim and Sunam Kim and Akihiro Suzuki and Yuki Takayama and Tomotaka Oroguchi and Yukio Takahashi and Jiadong Fan and Yunfei Zou and Takaki Hatsui and Yuichi Inubushi and Takashi Kameshima and Koji Yonekura and Kensuke Tono and Tadashi Togashi and Takahiro Sato and Masaki Yamamoto and Masayoshi Nakasako and Makina Yabashi and Tetsuya Ishikawa and Jianwei Miao",
note = "Funding Information: We thank Haibing Xia for providing monodisperse trisoctahedral gold nanocrystals used for this study, Margaret M. Murnane, Z. Hong Zhou and Xing Zhang for stimulating discussions. This work was supported by the DARPA PULSE program through a grant from AMRDEC and the Institute of Physical and Chemical Research (RIKEN) of Japan. The experiments were performed at SACLA with the approval of JASRI and the programme review committee (No. 2012A8027). H.J. acknowledges the support by the National Natural Science Foundation of China (No.21390414) and J.A.R. is supported by a Giannini Foundation postdoctoral fellowship. M.G.-J. is supported by the RIKEN-Liverpool partnership award shared with T.I. and Samar Hasnain.",
year = "2014",
month = jun,
day = "5",
doi = "10.1038/ncomms5061",
language = "English",
volume = "5",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}