TY - JOUR
T1 - Single-stranded β-1,3–1,6-glucan as a carrier for improved dissolution and membrane permeation of poorly water-soluble compounds
AU - Uchiyama, Hiromasa
AU - Dowaki, Mayu
AU - Kadota, Kazunori
AU - Arima, Hiroshi
AU - Sugiyama, Kazumasa
AU - Tozuka, Yuichi
N1 - Funding Information:
The authors are grateful to Itochu Sugar Co., Ltd. (Kururu no β-glu®, Japan, Aichi) for gifting ssβ-glucan. This work was performed under the Inter-University Cooperative Research Program of the Institute for Materials Research, Tohoku University (Proposal No. 18K0025).
Funding Information:
The authors are grateful to Itochu Sugar Co. Ltd. (Kururu no ?-glu?, Japan, Aichi) for gifting ss?-glucan. This work was performed under the Inter-University Cooperative Research Program of the Institute for Materials Research, Tohoku University (Proposal No. 18K0025).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11/1
Y1 - 2020/11/1
N2 - The ability of a water-soluble, single-stranded β-1,3/1,6-glucan (ssβ-glucan), recovered by hydrothermal treatment, to enhance the solubility and membrane permeability of poorly water-soluble compounds was examined. As a poorly water-soluble model compound, quercetin (QUE) was used. The aqueous solubility of spray-dried particles (SDPs) of QUE/ssβ-glucan was significantly enhanced compared with that of the untreated QUE powder and the physical mixture of QUE/ssβ-glucan. Fourier-transform infrared spectra and small-angle X-ray scattering suggested strong interactions between ssβ-glucan and QUE in the SDPs, which was attributable to QUE entrapment in the helical ssβ-glucan structure. The amount of QUE infused into Caco-2 cells from QUE/ssβ-glucan SDPs was 16-fold and 5-fold higher than the amount infused from untreated QUE powder and the physical mixture of QUE/ssβ-glucan, respectively. These results showed that water-soluble ssβ-glucan improved QUE dissolution and membrane permeability.
AB - The ability of a water-soluble, single-stranded β-1,3/1,6-glucan (ssβ-glucan), recovered by hydrothermal treatment, to enhance the solubility and membrane permeability of poorly water-soluble compounds was examined. As a poorly water-soluble model compound, quercetin (QUE) was used. The aqueous solubility of spray-dried particles (SDPs) of QUE/ssβ-glucan was significantly enhanced compared with that of the untreated QUE powder and the physical mixture of QUE/ssβ-glucan. Fourier-transform infrared spectra and small-angle X-ray scattering suggested strong interactions between ssβ-glucan and QUE in the SDPs, which was attributable to QUE entrapment in the helical ssβ-glucan structure. The amount of QUE infused into Caco-2 cells from QUE/ssβ-glucan SDPs was 16-fold and 5-fold higher than the amount infused from untreated QUE powder and the physical mixture of QUE/ssβ-glucan, respectively. These results showed that water-soluble ssβ-glucan improved QUE dissolution and membrane permeability.
KW - Permeability enhancement
KW - Quercetin
KW - Solubility enhancement
KW - β-1,3/1,6-Glucan
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U2 - 10.1016/j.carbpol.2020.116698
DO - 10.1016/j.carbpol.2020.116698
M3 - Article
C2 - 32829826
AN - SCOPUS:85087332906
SN - 0144-8617
VL - 247
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 116698
ER -