Site-specific modification of RNA by functionality-transfer ODN probes.

Kazumitsu Onizuka; Yosuke Taniguchi; Takamasa Nishioka; Shigeki Sasaki

Site-specific modification of RNA by functionality-transfer ODN probes.

Kazumitsu Onizuka, Yosuke Taniguchi, Takamasa Nishioka, Shigeki Sasaki

IMRAM - Division of Organic- and Biomaterials Research

Kyushu University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Efficient methods for the modification of RNA molecules have been expected as innovative biological tools and therapeutic methods. In this study, the development of a general method for site-specific RNA modification by the functionality-transfer ODN probes has been investigated. Site-specific and cytosine-selective RNA modifications were achieved by the functionality-transfer reaction. It was shown that the base and site-selectivity were due to the close proximity of the reactants in the DNA-RNA duplexes.

Original language	English
Pages (from-to)	67-68
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	53
Publication status	Published - 2009

Cite this

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abstract = "Efficient methods for the modification of RNA molecules have been expected as innovative biological tools and therapeutic methods. In this study, the development of a general method for site-specific RNA modification by the functionality-transfer ODN probes has been investigated. Site-specific and cytosine-selective RNA modifications were achieved by the functionality-transfer reaction. It was shown that the base and site-selectivity were due to the close proximity of the reactants in the DNA-RNA duplexes.",

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AB - Efficient methods for the modification of RNA molecules have been expected as innovative biological tools and therapeutic methods. In this study, the development of a general method for site-specific RNA modification by the functionality-transfer ODN probes has been investigated. Site-specific and cytosine-selective RNA modifications were achieved by the functionality-transfer reaction. It was shown that the base and site-selectivity were due to the close proximity of the reactants in the DNA-RNA duplexes.

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Site-specific modification of RNA by functionality-transfer ODN probes.

Abstract

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