Recent progress on the accelerator science requires optimized phase space distributions of the beam for each applications. A classical approach to satisfy the requirements is minimizing the beam emittance with a bunch charge as much as possible. This classical approach is not efficient and not compatible to the beam dynamics nature. 6D phase-space rotation, e.g. z-x and x-y, gives a way to optimize the phase space distribution for various applications. In this article, we discus possible applications of the 6D phase space rotation. The x-y rotation generates the high aspect ratio beam for linear colliders directly without DR (Damping Ring). Combination of bunch clipping with a mechanical slit and x-z rotation can generate micro-bunch structure which is applicable for FEL enhancement and drive beam for dielectric acceleration. We present our theoretical and simulation study on these applications.