Size separation of carbon nanotubes for biomedical applications

Yoshinori Sato, Yuki Akimoto, Balachandran Jeyadevan, Kenichi Motomiya, Rikizo Hatakeyama, Kazuchika Tamura, Tsukasa Akasaka, Motohiro Uo, Atsuro Yokoyama, Ken Ichiro Shibata, Fumio Watari, Kazuyuki Tohji

Research output: Contribution to journalConference articlepeer-review


In this paper, we report the results of an attempt to disperse MWCNTs in water and determine their biocompatibilities. The length of the MWCNTs was reduced by treating the acidic nanotube suspension with ultrasonic irradiation. Then, the cut nanotubes were size-separated into 670, 550 and 220 nm length by filtration using polycarbonate membrane filters. The neutrophils activity (TNF-α) of size-separated MWCNTs was low and confirmed biocompatible.

Original languageEnglish
Article number02
Pages (from-to)13-17
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2004
EventNanosensing Materials and Devices - Philadelphia, PA, United States
Duration: 2004 Oct 252004 Oct 28


  • Biocompatibility
  • Multi-walled carbon nanotubes (MWCNTs)
  • Neutrophils activity
  • Size separation
  • TNF-α


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