Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products

Masato Oikawa; Shinya Naito; Makoto Sasaki

doi:10.1016/j.tetlet.2006.04.098

Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products

Masato Oikawa, Shinya Naito, Makoto Sasaki

LIF - Molecular and Chemical Life Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Here, we report a diversity-oriented synthetic approach toward skeletally diverse, cyclized peptidomimetics with diverse appendages. Starting from α-(N-acylamino)amides with various appendages, 12 to 16-membered lactams with defined olefin geometry were synthesized by a common synthetic sequence. We also synthesized the macrocycle in a liquid phase directed toward a construction of the peptidomimetics library.

Original language	English
Pages (from-to)	4763-4767
Number of pages	5
Journal	Tetrahedron Letters
Volume	47
Issue number	27
DOIs	https://doi.org/10.1016/j.tetlet.2006.04.098
Publication status	Published - 2006 Jul 3

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10.1016/j.tetlet.2006.04.098

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abstract = "Here, we report a diversity-oriented synthetic approach toward skeletally diverse, cyclized peptidomimetics with diverse appendages. Starting from α-(N-acylamino)amides with various appendages, 12 to 16-membered lactams with defined olefin geometry were synthesized by a common synthetic sequence. We also synthesized the macrocycle in a liquid phase directed toward a construction of the peptidomimetics library.",

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Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products

Abstract

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