TY - JOUR
T1 - Skin advanced glycation end product accumulation and muscle strength among adult men
AU - Momma, Haruki
AU - Niu, Kaijun
AU - Kobayashi, Yoritoshi
AU - Guan, Lei
AU - Sato, Mika
AU - Guo, Hui
AU - Chujo, Masahiko
AU - Otomo, Atsushi
AU - Yufei, Cui
AU - Tadaura, Hiroko
AU - Saito, Tatsunori
AU - Mori, Takefumi
AU - Miyata, Toshio
AU - Nagatomi, Ryoichi
N1 - Funding Information:
Acknowledgments We gratefully acknowledge all the subjects for participating in our study and the Sendai Oroshisho Center for allowing us to perform the study. This work was supported by a Grant-in-Aid under the ‘‘Knowledge Cluster Initiative’’ from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The present study complies with the current laws of Japan and the protocol of the present study was approved by the Institutional Review Board of the Tohoku University Graduate School of Medicine.
PY - 2011/7
Y1 - 2011/7
N2 - Aging is associated with decreased skeletal muscle function. Increased levels of advanced glycation end products (AGEs) in skeletal muscle tissue are observed with advancing age and in diabetes. Although serum AGE level is negatively associated with grip strength in elderly people, it is unknown whether this association is present in adult males. To determine the relationship between AGE accumulation in tissue and muscle strength and power among Japanese adult men. Skin autofluorescence (AF) (a noninvasive method for measuring tissue AGEs), grip strength (n = 232), and leg extension power (n = 138) were measured in Japanese adult men [median (interquartile range) age, 46.0 (37.0, 56.0) years]. After adjustment for potential confounders, the adjusted means [95% confidence interval (CI)] for grip strength across the tertiles of skin AF were 44.5 (43.2, 45.9) kg for the lowest tertile, 42.0 (40.6, 43.3) kg for the middle tertile, and 41.7 (40.3, 43.1) kg for the highest tertile (P for trend<0.01). Moreover, the adjusted geometric means (95% CI) of leg extension power across the tertiles of skin AF were 17.8 (16.6, 19.1) W/kg for the lowest tertile, 17.5 (16.4, 18.7) W/kg for the middle tertile, and 16.0 (14.9, 17.1) W/kg for the highest tertile (P for trend < 0.04). Among Japanese adult men, participants with higher skin AF had lower muscle strength and power, indicating a relationship between AGE accumulation and muscle strength and power. A long-term prospective study is required to clarify the causality.
AB - Aging is associated with decreased skeletal muscle function. Increased levels of advanced glycation end products (AGEs) in skeletal muscle tissue are observed with advancing age and in diabetes. Although serum AGE level is negatively associated with grip strength in elderly people, it is unknown whether this association is present in adult males. To determine the relationship between AGE accumulation in tissue and muscle strength and power among Japanese adult men. Skin autofluorescence (AF) (a noninvasive method for measuring tissue AGEs), grip strength (n = 232), and leg extension power (n = 138) were measured in Japanese adult men [median (interquartile range) age, 46.0 (37.0, 56.0) years]. After adjustment for potential confounders, the adjusted means [95% confidence interval (CI)] for grip strength across the tertiles of skin AF were 44.5 (43.2, 45.9) kg for the lowest tertile, 42.0 (40.6, 43.3) kg for the middle tertile, and 41.7 (40.3, 43.1) kg for the highest tertile (P for trend<0.01). Moreover, the adjusted geometric means (95% CI) of leg extension power across the tertiles of skin AF were 17.8 (16.6, 19.1) W/kg for the lowest tertile, 17.5 (16.4, 18.7) W/kg for the middle tertile, and 16.0 (14.9, 17.1) W/kg for the highest tertile (P for trend < 0.04). Among Japanese adult men, participants with higher skin AF had lower muscle strength and power, indicating a relationship between AGE accumulation and muscle strength and power. A long-term prospective study is required to clarify the causality.
KW - Advanced glycation end products
KW - Carbonyl stress
KW - Grip strength
KW - Legextension power
KW - Oxidative stress
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U2 - 10.1007/s00421-010-1779-x
DO - 10.1007/s00421-010-1779-x
M3 - Article
C2 - 21188413
AN - SCOPUS:80053999424
SN - 1439-6319
VL - 111
SP - 1545
EP - 1552
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 7
ER -
