Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type2 diabetes

K. Tanaka, Y. Tani, J. Asai, F. Nemoto, Y. Kusano, H. Suzuki, Y. Hayashi, K. Asahi, M. Nakayama, T. Miyata, T. Watanabe

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Aims Skin autofluorescence, a non-invasive measure of the accumulation for advanced glycation end products, has been reported to be a useful marker for diabetic vascular risks in the Caucasian population. The aim of this study was to evaluate associations between skin autofluorescence and vascular complications in non-Caucasian patients with Type2 diabetes. Methods Subjects in this cross-sectional study comprised 130 Japanese patients with Type2 diabetes. Skin advanced glycation end products were assessed by skin autofluorescence using an autofluorescence reader. Association between skin autofluorescence and severity of vascular complications was evaluated. Results Of the 130 patients, 60 (46.2%) had microvascular complications such as diabetic retinopathy, neuropathy and nephropathy, 10 (7.7%) had macrovascular complications and 63 (48.5%) had micro- and/or macrovascular complications. Skin autofluorescence increased with severity of vascular complications. Independent determinants of skin autofluorescence were age (β=0.24, P<0.01), mean HbA 1c in previous year (β=0.17, P=0.03), microvascular complications (β=0.44, P<0.01) and macrovascular complications (β=0.27, P<0.01). Multiple logistic regression analysis revealed that diabetes duration (odds ratio 1.15, P<0.01), systolic blood pressure (odds ratio 1.04, P=0.01), skin autofluorescence (odds ratio 3.62, P=0.01) and serum albumin (odds ratio 0.84, P<0.01) were independent factors for the presence of vascular complications in these patients. Conclusions Skin autofluorescence had independent effects on vascular complications in Japanese patients with Type2 diabetes. This indicates that skin advanced glycation end products are a surrogate marker for vascular risk and a non-invasive autofluorescence reader may be a useful tool to detect high-risk cases in non-Caucasian patients with diabetes.

Original languageEnglish
Pages (from-to)492-500
Number of pages9
JournalDiabetic Medicine
Issue number4
Publication statusPublished - 2012 Apr


  • Advanced glycation end products
  • Diabetes
  • Vascular


Dive into the research topics of 'Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type2 diabetes'. Together they form a unique fingerprint.

Cite this