Sleep duration during weekdays affects hippocampal gray matter volume in healthy children

Yasuyuki Taki; Hiroshi Hashizume; Benjamin Thyreau; Yuko Sassa; Hikaru Takeuchi; Kai Wu; Yuka Kotozaki; Rui Nouchi; Michiko Asano; Kohei Asano; Hiroshi Fukuda; Ryuta Kawashima

doi:10.1016/j.neuroimage.2011.11.072

Sleep duration during weekdays affects hippocampal gray matter volume in healthy children

Yasuyuki Taki, Hiroshi Hashizume, Benjamin Thyreau, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Yuka Kotozaki, Rui Nouchi, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18. years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.

Original language	English
Pages (from-to)	471-475
Number of pages	5
Journal	NeuroImage
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroimage.2011.11.072
Publication status	Published - 2012 Mar

Keywords

Children
Gray matter
Hippocampus
Sleep
Voxel-based morphometry

ASJC Scopus subject areas

Neurology
Cognitive Neuroscience

Access to Document

10.1016/j.neuroimage.2011.11.072

Cite this

@article{08f6627747114ffc980db38325385d29,

title = "Sleep duration during weekdays affects hippocampal gray matter volume in healthy children",

abstract = "Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18. years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.",

keywords = "Children, Gray matter, Hippocampus, Sleep, Voxel-based morphometry",

author = "Yasuyuki Taki and Hiroshi Hashizume and Benjamin Thyreau and Yuko Sassa and Hikaru Takeuchi and Kai Wu and Yuka Kotozaki and Rui Nouchi and Michiko Asano and Kohei Asano and Hiroshi Fukuda and Ryuta Kawashima",

note = "Funding Information: We thank Y. Yamada for collecting MR data, and Y. Suzuki for technical support. This work was supported by a Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Young Scientists (B) (grant number 20790875 ).",

year = "2012",

month = mar,

doi = "10.1016/j.neuroimage.2011.11.072",

language = "English",

volume = "60",

pages = "471--475",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Sleep duration during weekdays affects hippocampal gray matter volume in healthy children

AU - Taki, Yasuyuki

AU - Hashizume, Hiroshi

AU - Thyreau, Benjamin

AU - Sassa, Yuko

AU - Takeuchi, Hikaru

AU - Wu, Kai

AU - Kotozaki, Yuka

AU - Nouchi, Rui

AU - Asano, Michiko

AU - Asano, Kohei

AU - Fukuda, Hiroshi

AU - Kawashima, Ryuta

N1 - Funding Information: We thank Y. Yamada for collecting MR data, and Y. Suzuki for technical support. This work was supported by a Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Young Scientists (B) (grant number 20790875 ).

PY - 2012/3

Y1 - 2012/3

N2 - Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18. years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.

AB - Sleep is essential for living beings, and sleep loss has been shown to affect hippocampal structure and function in rats by inhibiting cell proliferation and neurogenesis in this region of the brain. We aimed to analyze the correlation between sleep duration and the hippocampal volume using brain magnetic resonance images of 290 healthy children aged 5-18. years. We examined the volume of gray matter, white matter, and the cerebrospinal fluid (CSF) space in the brain using a fully automated and established neuroimaging technique, voxel-based morphometry, which enabled global analysis of brain structure without bias towards any specific brain region while permitting the identification of potential differences or abnormalities in brain structures. We found that the regional gray matter volume of the bilateral hippocampal body was significantly positively correlated with sleep duration during weekdays after adjusting for age, sex, and intracranial volume. Our results indicated that sleep duration affects the hippocampal regional gray matter volume of healthy children. These findings advance our understanding of the importance of sleep habits in the daily lives of healthy children.

KW - Children

KW - Gray matter

KW - Hippocampus

KW - Sleep

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=84856101840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856101840&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2011.11.072

DO - 10.1016/j.neuroimage.2011.11.072

M3 - Article

C2 - 22197742

AN - SCOPUS:84856101840

SN - 1053-8119

VL - 60

SP - 471

EP - 475

JO - NeuroImage

JF - NeuroImage

IS - 1

ER -

Sleep duration during weekdays affects hippocampal gray matter volume in healthy children

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this