Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Yusuke Mita; Tomomi Noguchi-Yachide; Minoru Ishikawa; Yuichi Hashimoto

doi:10.1016/j.bmc.2012.11.054

Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Yusuke Mita, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.

Original language	English
Pages (from-to)	608-617
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.bmc.2012.11.054
Publication status	Published - 2013 Feb 1
Externally published	Yes

Keywords

Inhibitor
Non-ATP-competitive
Non-peptide
Polo-like kinase
Small molecule
Terphenyl skeleton

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2012.11.054

Cite this

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title = "Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton",

abstract = "Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.",

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author = "Yusuke Mita and Tomomi Noguchi-Yachide and Minoru Ishikawa and Yuichi Hashimoto",

note = "Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan , and the Japan Society for the Promotion of Science .",

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T1 - Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

AU - Mita, Yusuke

AU - Noguchi-Yachide, Tomomi

AU - Ishikawa, Minoru

AU - Hashimoto, Yuichi

N1 - Funding Information: The work described in this paper was partially supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan , and the Japan Society for the Promotion of Science .

PY - 2013/2/1

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N2 - Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.

AB - Polo-like kinase (Plk) 1 is a serine-threonine protein kinase that plays a role in cell division, and its overexpression is highly correlated with aggressiveness and prognosis of many cancers. We have designed, synthesized and evaluated a series of terphenyl compounds as inhibitors of the kinase activity of Plk1. Some of them act as non-ATP-competitive Plk1 inhibitors.

KW - Inhibitor

KW - Non-ATP-competitive

KW - Non-peptide

KW - Polo-like kinase

KW - Small molecule

KW - Terphenyl skeleton

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Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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