Hydrogenolysis of aqueous glycerol was conducted with Ir-ReO x/SiO 2 catalyst and solid acid co-catalyst. Considering the reusability and activity, H-ZSM-5 is the most suitable solid co-catalyst. The property of Ir-ReO x/SiO 2 + H-ZSM-5 system including kinetics and selectivity trends in various reaction conditions is similar to the case of Ir-ReO x/SiO 2 + H 2SO 4. The catalyst stability, activity, and the maximum yield of 1,3-PrD of Ir-ReO x/SiO 2 + H-ZSM-5 were slightly lower than Ir-ReO x/SiO 2 + H 2SO 4. The role of added acid may be to protonate the surface of ReO x cluster to increase the number of hydroxorhenium site, which activates glycerol by the formation of glyceride species.