Somatic cell conversion to a germ cell lineage: A violation or a revelation?

Gary M. Wessel, Shumpei Morita, Nathalie Oulhen

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

The germline is unique and immortal (or at least its genome is). It is able to perform unique jobs (meiosis) and is selected for genetic changes. Part of being this special also means that entry into the germline club is restricted and cells of the soma are always left out. However, the recent evidence from multiple animals now suggests that somatic cells may join the club and become germline cells in an animal when the original germline is removed. This “violation” may have garnered acceptance by the observation that iPScells, originating experimentally from somatic cells of an adult, can form reproductively successful eggs and sperm, all in vitro. Each of the genes and their functions used to induce pluripotentiality are found normally in the cell and the in vitro conditions to direct germline commitment replicate conditions in vivo. Here, we discuss evidence from three different animals: an ascidian, a segmented worm, and a sea urchin; and that the cells of a somatic cell lineage can convert into the germline in vivo. We discuss the consequences of such transitions and provide thoughts as how this process may have equal precision to the original germline formation of an embryo.

Original languageEnglish
Pages (from-to)666-679
Number of pages14
JournalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
Volume336
Issue number8
DOIs
Publication statusPublished - 2021 Dec

Keywords

  • cell fate conversion
  • germ cell
  • germline
  • soma

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