Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Maxime Lafond, Shin Yoshizawa, Shin ichiro Umemura

Research output: Contribution to journalReview articlepeer-review

97 Citations (Scopus)


Sonodynamic therapy (SDT) consists of the synergetic interaction between ultrasound and a chemical agent. In SDT, the cytotoxicity is triggered by ultrasonic stimuli, notably through cavitation. The unique features of SDT are relevant in the clinical context more than ever: the need for efficacy, accuracy, and safety while being noninvasive and preserving the patient's quality of life. However, despite the promising results of this technique, only a few clinical reports describe the use of SDT. The objective of this article is to provide an extensive overview of the clinical and preclinical research conducted in vivo on SDT, to identify the limitations, and to detail the developed strategies to overcome them.

Original languageEnglish
Pages (from-to)567-580
Number of pages14
JournalJournal of Ultrasound in Medicine
Issue number3
Publication statusPublished - 2019 Mar


  • cancer
  • cavitation
  • clinical translation
  • sonodynamic therapy
  • ultrasound


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