Spatial and topological distribution of progesterone receptor A and B isoforms during human development

Tsukasa Inoue, Jun Ichi Akahira, Junji Takeyama, Takashi Suzuki, Andrew D. Darnel, Chika Kaneko, Yoshimochi Kurokawa, Susumu Satomi, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Progesterone receptor (PR) is a member of the nuclear receptor superfamily. To date, two isoforms of PR have been identified, PR-A and PR-B. In progesterone responsive tissues, the relative ratio of PR-A and PR-B is considered to contribute to the tissue-specific actions of progesterone. In this study, we examined the distribution of PR-A and PR-B in human fetal tissues ranging from 11 to 40 gestational weeks using immunohistochemistry and RT-PCR analysis. PR immunoreactivity was detected in a wide range of fetal tissues until 20 weeks of gestation, but gradually decreased towards the late gestational period. However, PR continued to remain positive throughout the gestational period in the interstitial cells of Cajal and endocrine tissues. PR-B was demonstrated as the predominant isoform in comparison to PR-A in all fetal tissues examined. These findings suggest that progesterone may be involved in the development of fetal organs throughout the gestational period.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalMolecular and Cellular Endocrinology
Issue number1
Publication statusPublished - 2001 Aug 20


  • Human fetal tissue
  • Immunohistochemistry
  • Progesterone receptor
  • Reverse transcriptase-polymerase chain reaction


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