TY - JOUR
T1 - Specific increase of Fusobacterium in the faecal microbiota of neonatal calves infected with Cryptosporidium parvum
AU - Ichikawa-Seki, Madoka
AU - Motooka, Daisuke
AU - Kinami, Aiko
AU - Murakoshi, Fumi
AU - Takahashi, Yoko
AU - Aita, Junya
AU - Hayashi, Kei
AU - Tashibu, Atsushi
AU - Nakamura, Shota
AU - Iida, Tetsuya
AU - Horii, Toshihiro
AU - Nishikawa, Yoshifumi
N1 - Funding Information:
This study was supported in part by a Joint Research Grant from the National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine (27-joint-2, 28-joint-6), and by a Grant for Joint Research Project of the Research Institute for Microbial Diseases, Osaka University.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The faecal microbiota plays a critical role in host health, with alterations in the human faecal microbial composition associated with various conditions, particularly diarrhoeal diseases. However, little is known about microbial changes during cryptosporidiosis, one of the most important diarrhoeal diseases caused by protozoa in cattle. In this study, alterations in the faecal microbiota of neonatal calves as a result of Cryptosporidium parvum infection were investigated on a C. parvum-positive farm. Comparisons were made among groups of C. parvum-infected, rotavirus-infected, and the pathogen-negative calves. A specific increase in the abundance of Fusobacterium was observed in the faecal microbiota of C. parvum-infected animals. Diarrhoea severity increased in accordance with the abundance of C. parvum and Fusobacterium. Moreover, the specific increase of Fusobacterium appeared to be a universal feature of C. parvum infection, since neonatal calves from geographically separated areas showed the same result. These observations indicated that the growth of Fusobacterium may be an important aggravating factor of cryptosporidiosis.
AB - The faecal microbiota plays a critical role in host health, with alterations in the human faecal microbial composition associated with various conditions, particularly diarrhoeal diseases. However, little is known about microbial changes during cryptosporidiosis, one of the most important diarrhoeal diseases caused by protozoa in cattle. In this study, alterations in the faecal microbiota of neonatal calves as a result of Cryptosporidium parvum infection were investigated on a C. parvum-positive farm. Comparisons were made among groups of C. parvum-infected, rotavirus-infected, and the pathogen-negative calves. A specific increase in the abundance of Fusobacterium was observed in the faecal microbiota of C. parvum-infected animals. Diarrhoea severity increased in accordance with the abundance of C. parvum and Fusobacterium. Moreover, the specific increase of Fusobacterium appeared to be a universal feature of C. parvum infection, since neonatal calves from geographically separated areas showed the same result. These observations indicated that the growth of Fusobacterium may be an important aggravating factor of cryptosporidiosis.
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U2 - 10.1038/s41598-019-48969-6
DO - 10.1038/s41598-019-48969-6
M3 - Article
C2 - 31467354
AN - SCOPUS:85071742053
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 12517
ER -
