TY - JOUR
T1 - Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton
AU - Matsumoto, Yotaro
AU - Noguchi-Yachide, Tomomi
AU - Nakamura, Masaharu
AU - Mita, Yusuke
AU - Numadate, Akiyoshi
AU - Hashimoto, Yuichi
PY - 2012
Y1 - 2012
N2 - Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.
AB - Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.
UR - http://www.scopus.com/inward/record.url?scp=84880578686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880578686&partnerID=8YFLogxK
U2 - 10.3987/COM-12-S(N)109
DO - 10.3987/COM-12-S(N)109
M3 - Article
AN - SCOPUS:84880578686
SN - 0385-5414
VL - 86
SP - 1449
EP - 1463
JO - Heterocycles
JF - Heterocycles
IS - 2
ER -