@article{0a070b4f232c48a4ae58e8bc7cf39e37,
title = "Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age",
abstract = "Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta{\texttrademark} mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10-5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10-5 at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.",
keywords = "Ageing, lacZ: Muta mouse, Spleen, Spontaneous mutation",
author = "T. Ono and Y. Miyamura and H. Ikehata and H. Yamanaka and A. Kurishita and K. Yamamoto and T. Suzuki and T. Nohmi and M. Hayashi and T. Sofuni",
note = "Funding Information: The authors thank Ms. Y. Syono for her excellent technical help, Dr. P.M. Glazer for providing us with E. co/i NM759 and BHB2688; Dr. B. Myhr for giving us permission to make embryos and newborns of MutaTM mouse by ourselves, and Dr. N. Nakamura for his valuable information and discussion. The work was supported in part by grants from Central Research Institute of Electric Power Industry, and Ministries of Health and Welfare; and Education Culture and Science of Japan.",
year = "1995",
month = oct,
doi = "10.1016/0921-8734(95)00023-Y",
language = "English",
volume = "338",
pages = "183--188",
journal = "Mutation Research DNAging",
issn = "0921-8734",
publisher = "Elsevier BV",
number = "1-6",
}