Stabilization of micropatterned polymer films as artificial extracellular matrices for tissue engineering

Ryusuke Ookura; Jin Nishida; Takehiro Nishikawa; Masatsugu Shimomura

doi:10.1080/10587259908023477

Stabilization of micropatterned polymer films as artificial extracellular matrices for tissue engineering

Ryusuke Ookura, Jin Nishida, Takehiro Nishikawa, Masatsugu Shimomura

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Honeycomb-patterned polymer films are formed upon self-organization of water microspheres stabilized by amphiphilic polymers. The honeycomb films can work as cell culture substrates. The films composed of heparin-cationic lipid complex, however, gradually lost the honeycomb structure when immersed in culture medium. Crosslinking of the films was carried to stabilize the honeycomb pattern. A bisazido derivative was used as a crosslinker connecting the constituent polymer of the honeycomb films. Morphological study of the immersed films revealed that the crosslinked films maintained the honeycomb structure in the phosphate buffer solution.

Original language	English
Pages (from-to)	461-464
Number of pages	4
Journal	Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals
Volume	337
DOIs	https://doi.org/10.1080/10587259908023477
Publication status	Published - 1999
Externally published	Yes

Keywords

Amphiphilic polymers
Cell adhesion
Honeycomb films
Photo-crosslinking

ASJC Scopus subject areas

Condensed Matter Physics

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10.1080/10587259908023477

Cite this

Stabilization of micropatterned polymer films as artificial extracellular matrices for tissue engineering. / Ookura, Ryusuke; Nishida, Jin; Nishikawa, Takehiro et al.
In: Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, Vol. 337, 1999, p. 461-464.

Research output: Contribution to journal › Article › peer-review

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AU - Nishida, Jin

AU - Nishikawa, Takehiro

AU - Shimomura, Masatsugu

PY - 1999

Y1 - 1999

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AB - Honeycomb-patterned polymer films are formed upon self-organization of water microspheres stabilized by amphiphilic polymers. The honeycomb films can work as cell culture substrates. The films composed of heparin-cationic lipid complex, however, gradually lost the honeycomb structure when immersed in culture medium. Crosslinking of the films was carried to stabilize the honeycomb pattern. A bisazido derivative was used as a crosslinker connecting the constituent polymer of the honeycomb films. Morphological study of the immersed films revealed that the crosslinked films maintained the honeycomb structure in the phosphate buffer solution.

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KW - Cell adhesion

KW - Honeycomb films

KW - Photo-crosslinking

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Stabilization of micropatterned polymer films as artificial extracellular matrices for tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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