Stage-specific gene expression in erythroid progenitor cells (CFU-E)

Yuji Mishina, Yasuhisa Matsui, Masuo Obinata

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


In erythropoietic differentiation, mature red blood cells are generated from specific progenitor cells through the action of specific growth regulatory molecules. To know the mechanism of differentiation, it is important to examine the control of gene expression in these progenitor cells in combination with growth regulatory molecules. We have cloned two genes expressing at a maximal level in the CFU-E (colony forming unit-erythroid), one of the erythroid progenitor cells from novel murine erythroleukemia (MEL) cell line (TSA8) which can be induced to CFU-E in vitro. The expression of these genes is well correlated with the appearance of CFU-E during induction of TSA8 cells, and is higher in the CFU-E-cells enriched from mouse fetal livers than in the more differentiated erythroid cells. Combining these with our previous results, it is suggested that in the erythropoiesis the progenitor cells have distinct patterns of gene expression. This expression is replaced through each progenitor cell rather than by the continuous increase in the expression of a set of genes specific to the mature erythroid cell following the commitment process.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalCell Differentiation
Issue number3
Publication statusPublished - 1988 Feb


  • CFU-E (colony forming unit-erythroid)
  • Induction-specific cDNA clone
  • Murine erythroleukemia cell
  • Sequential gene expression


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