TY - JOUR
T1 - Stem cells in dentistry - Part I
T2 - Stem cell sources
AU - Egusa, Hiroshi
AU - Sonoyama, Wataru
AU - Nishimura, Masahiro
AU - Atsuta, Ikiru
AU - Akiyama, Kentaro
N1 - Funding Information:
We are grateful to Prof. Songtao Shi (Center for Craniofacial Molecular Biology, University of Southern California) for critical reading of the manuscript. This review article was written as a project proposed by the Journal of Prosthodontic Research (JPR) Editorial Committee under the support of the Japan Prosthodontic Society (JPS). The authors thank Prof. Takuo Kuboki, the Editor-in-Chief of the JPR, and Prof. Kiyoshi Koyano, the President of the JPS, for their valuable support to accomplish this work. Support was also received from a Grant-in-Aid for Young Scientists (A22689049: H.E. and A22689050: W.S.) and for Scientific Research (B22390367: M.N.) from the Japan Society for the Promotion of Science .
PY - 2012/7
Y1 - 2012/7
N2 - Stem cells can self-renew and produce different cell types, thus providing new strategies to regenerate missing tissues and treat diseases. In the field of dentistry, adult mesenchymal stem/stromal cells (MSCs) have been identified in several oral and maxillofacial tissues, which suggests that the oral tissues are a rich source of stem cells, and oral stem and mucosal cells are expected to provide an ideal source for genetically reprogrammed cells such as induced pluripotent stem (iPS) cells. Furthermore, oral tissues are expected to be not only a source but also a therapeutic target for stem cells, as stem cell and tissue engineering therapies in dentistry continue to attract increasing clinical interest. Part I of this review outlines various types of intra- and extra-oral tissue-derived stem cells with regard to clinical availability and applications in dentistry. Additionally, appropriate sources of stem cells for regenerative dentistry are discussed with regard to differentiation capacity, accessibility and possible immunomodulatory properties.
AB - Stem cells can self-renew and produce different cell types, thus providing new strategies to regenerate missing tissues and treat diseases. In the field of dentistry, adult mesenchymal stem/stromal cells (MSCs) have been identified in several oral and maxillofacial tissues, which suggests that the oral tissues are a rich source of stem cells, and oral stem and mucosal cells are expected to provide an ideal source for genetically reprogrammed cells such as induced pluripotent stem (iPS) cells. Furthermore, oral tissues are expected to be not only a source but also a therapeutic target for stem cells, as stem cell and tissue engineering therapies in dentistry continue to attract increasing clinical interest. Part I of this review outlines various types of intra- and extra-oral tissue-derived stem cells with regard to clinical availability and applications in dentistry. Additionally, appropriate sources of stem cells for regenerative dentistry are discussed with regard to differentiation capacity, accessibility and possible immunomodulatory properties.
KW - Dental stem cells
KW - Induced pluripotent stem cells
KW - Mesenchymal stem cells
KW - Regenerative dentistry
KW - Stem cell sources
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U2 - 10.1016/j.jpor.2012.06.001
DO - 10.1016/j.jpor.2012.06.001
M3 - Review article
C2 - 22796367
AN - SCOPUS:84869861786
SN - 1883-1958
VL - 56
SP - 151
EP - 165
JO - Nippon Hotetsu Shika Gakkai zasshi
JF - Nippon Hotetsu Shika Gakkai zasshi
IS - 3
ER -