Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel

Kazuoki Nakai; Miyuki Kamoshita; Takayuki Doi; Haruo Yamada; Takashi Takahashi

doi:10.1016/S0040-4039(01)01655-0

Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel

Kazuoki Nakai, Miyuki Kamoshita, Takayuki Doi, Haruo Yamada, Takashi Takahashi

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.

Original language	English
Pages (from-to)	7855-7857
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	44
DOIs	https://doi.org/10.1016/S0040-4039(01)01655-0
Publication status	Published - 2001 Oct 29
Externally published	Yes

Keywords

Cyclisation
Epoxides
Stereocontrol
Taxoids
Titanium and compounds

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01655-0

Cite this

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title = "Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel",

abstract = "We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.",

keywords = "Cyclisation, Epoxides, Stereocontrol, Taxoids, Titanium and compounds",

author = "Kazuoki Nakai and Miyuki Kamoshita and Takayuki Doi and Haruo Yamada and Takashi Takahashi",

year = "2001",

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T1 - Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes

T2 - Synthesis of the A and C ring synthons of paclitaxel

AU - Nakai, Kazuoki

AU - Kamoshita, Miyuki

AU - Doi, Takayuki

AU - Yamada, Haruo

AU - Takahashi, Takashi

PY - 2001/10/29

Y1 - 2001/10/29

N2 - We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.

AB - We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.

KW - Cyclisation

KW - Epoxides

KW - Stereocontrol

KW - Taxoids

KW - Titanium and compounds

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U2 - 10.1016/S0040-4039(01)01655-0

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M3 - Article

AN - SCOPUS:0035968967

SN - 0040-4039

VL - 42

SP - 7855

EP - 7857

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 44

ER -

Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel

Abstract

Keywords

ASJC Scopus subject areas

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