Stereocontrolled total synthesis of (+)-vinblastine

Satoshi Yokoshima; Toshihiro Ueda; Satoshi Kobayashi; Ayato Sato; Takeshi Kuboyama; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1021/ja0177049

Stereocontrolled total synthesis of (+)-vinblastine

Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, Tohru Fukuyama

PHA - Molecular Pharmaceutical Science

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

224 Citations (Scopus)

Abstract

A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.

Original language	English
Pages (from-to)	2137-2139
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	124
Issue number	10
DOIs	https://doi.org/10.1021/ja0177049
Publication status	Published - 2002 Mar 13

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10.1021/ja0177049

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title = "Stereocontrolled total synthesis of (+)-vinblastine",

abstract = "A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.",

author = "Satoshi Yokoshima and Toshihiro Ueda and Satoshi Kobayashi and Ayato Sato and Takeshi Kuboyama and Hidetoshi Tokuyama and Tohru Fukuyama",

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AU - Yokoshima, Satoshi

AU - Ueda, Toshihiro

AU - Kobayashi, Satoshi

AU - Sato, Ayato

AU - Kuboyama, Takeshi

AU - Tokuyama, Hidetoshi

AU - Fukuyama, Tohru

PY - 2002/3/13

Y1 - 2002/3/13

N2 - A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.

AB - A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 10

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Stereocontrolled total synthesis of (+)-vinblastine

Abstract

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