Stereoselective construction of cis-decalin framework via radical domino cyclization

Eriko Suzuki; Minoru Ueda; Shigeru Ohba; Takeshi Sugai; Mitsuru Shoji

doi:10.1016/j.tetlet.2013.01.050

Stereoselective construction of cis-decalin framework via radical domino cyclization

Eriko Suzuki, Minoru Ueda, Shigeru Ohba, Takeshi Sugai, Mitsuru Shoji

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Steroids with A/B cis-decalin moiety and various bioactivities have attracted many synthetic chemists as target molecules and development of efficient methodology providing cis-decalins has been desired. A stereoselective domino cyclization via Mn(OAc)₃ and Cu(OTf)₂-mediated radical reaction was found to be effective to construct cis-decalin framework.

Original language	English
Pages (from-to)	1589-1592
Number of pages	4
Journal	Tetrahedron Letters
Volume	54
Issue number	12
DOIs	https://doi.org/10.1016/j.tetlet.2013.01.050
Publication status	Published - 2013 Mar 20

Keywords

cis-Decalin
Domino reaction
Radical cyclization
Stereoselective synthesis
Steriod

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10.1016/j.tetlet.2013.01.050

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abstract = "Steroids with A/B cis-decalin moiety and various bioactivities have attracted many synthetic chemists as target molecules and development of efficient methodology providing cis-decalins has been desired. A stereoselective domino cyclization via Mn(OAc)3 and Cu(OTf)2-mediated radical reaction was found to be effective to construct cis-decalin framework.",

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T1 - Stereoselective construction of cis-decalin framework via radical domino cyclization

AU - Suzuki, Eriko

AU - Ueda, Minoru

AU - Ohba, Shigeru

AU - Sugai, Takeshi

AU - Shoji, Mitsuru

PY - 2013/3/20

Y1 - 2013/3/20

N2 - Steroids with A/B cis-decalin moiety and various bioactivities have attracted many synthetic chemists as target molecules and development of efficient methodology providing cis-decalins has been desired. A stereoselective domino cyclization via Mn(OAc)3 and Cu(OTf)2-mediated radical reaction was found to be effective to construct cis-decalin framework.

AB - Steroids with A/B cis-decalin moiety and various bioactivities have attracted many synthetic chemists as target molecules and development of efficient methodology providing cis-decalins has been desired. A stereoselective domino cyclization via Mn(OAc)3 and Cu(OTf)2-mediated radical reaction was found to be effective to construct cis-decalin framework.

KW - cis-Decalin

KW - Domino reaction

KW - Radical cyclization

KW - Stereoselective synthesis

KW - Steriod

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M3 - Article

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VL - 54

SP - 1589

EP - 1592

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 12

ER -

Stereoselective construction of cis-decalin framework via radical domino cyclization

Abstract

Keywords

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