Abstract
(Chemical equation presented) The first asymmetric total syntheses of ent-El-1941-2 and epi-ent-El-1941-2 have been accomplished, starting from a chiral epoxy iodoquinone 6, a key intermediate in our total syntheses of epoxyquinols A and B. A key step in the preparation of ent-El-1941-2 is an intramolecular carboxypalladation via a 6-endo cyclization mode, followed by β-hydride elimination, while carboxymercuration is a key step in the synthesis of epi-ent-El-1941-2.
| Original language | English |
|---|---|
| Pages (from-to) | 4535-4538 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 6 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 2004 Nov 25 |