TY - JOUR
T1 - Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer
AU - Yue, Xiaoni
AU - Akahira, Jun Ichi
AU - Utsunomiya, Hiroki
AU - Miki, Yasuhiro
AU - Takahashi, Naomi
AU - Niikura, Hitoshi
AU - Ito, Kiyoshi
AU - Sasano, Hironobu
AU - Okamura, Kunihiro
AU - Yaegashi, Nobuo
PY - 2010/5
Y1 - 2010/5
N2 - We examined the expression of the steroid and xenobiotic receptor (SXR) and evaluated its clinical significance in human epithelial ovarian carcinoma. One hundred forty-one cases were examined using immunohistochemistry for SXR with archival specimens. All cases were scored using a semi-quantitative histological scoring (HSCORE) method. Specimens with an HSCORE > 60 were regarded as SXR-positive. Various clinicopathologic variables were examined. SXR showed significant differences in age, histology, grade, ERα and PR. SXR was detected in 35 of 141 (24.8%) ovarian cancer tissues. There was a statistically significant negative correlation between SXR-positive status and both disease-free survival and overall survival (P = 0.0415 and 0.0316, respectively), independent of stage (P = 0.0167 and 0.021, respectively). In multivariate analysis, SXR was a statistically independent risk factor for both disease-free survival and overall survival (P = 0.049 and 0.0354). Our results support an association of SXR between ERα and PR in epithelial ovarian cancers. Our data suggest that SXR is a prognostic factor in epithelial ovarian cancer and may represent a useful marker to identify patients at risk of recurrence or death.
AB - We examined the expression of the steroid and xenobiotic receptor (SXR) and evaluated its clinical significance in human epithelial ovarian carcinoma. One hundred forty-one cases were examined using immunohistochemistry for SXR with archival specimens. All cases were scored using a semi-quantitative histological scoring (HSCORE) method. Specimens with an HSCORE > 60 were regarded as SXR-positive. Various clinicopathologic variables were examined. SXR showed significant differences in age, histology, grade, ERα and PR. SXR was detected in 35 of 141 (24.8%) ovarian cancer tissues. There was a statistically significant negative correlation between SXR-positive status and both disease-free survival and overall survival (P = 0.0415 and 0.0316, respectively), independent of stage (P = 0.0167 and 0.021, respectively). In multivariate analysis, SXR was a statistically independent risk factor for both disease-free survival and overall survival (P = 0.049 and 0.0354). Our results support an association of SXR between ERα and PR in epithelial ovarian cancers. Our data suggest that SXR is a prognostic factor in epithelial ovarian cancer and may represent a useful marker to identify patients at risk of recurrence or death.
KW - Histological scoring (HSCORE)
KW - Immunohistochemistry
KW - Ovarian cancer
KW - Steroid and xenobiotic receptor (SXR)
UR - http://www.scopus.com/inward/record.url?scp=77951930753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951930753&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1827.2010.02546.x
DO - 10.1111/j.1440-1827.2010.02546.x
M3 - Article
C2 - 20518891
AN - SCOPUS:77951930753
SN - 1320-5463
VL - 60
SP - 400
EP - 406
JO - Pathology International
JF - Pathology International
IS - 5
ER -
