Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity

Arno R.N. Donfack; Ngeh J. Toyang; Hippolyte K. Wabo; Pierre Tane; Maurice D. Awouafack; Haruhisa Kikuchi; Jean D.D. Tamokou; Jules R. Kuiate; Yoshiteru Oshima

doi:10.1016/j.phytol.2012.06.002

Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity

Arno R.N. Donfack, Ngeh J. Toyang, Hippolyte K. Wabo, Pierre Tane, Maurice D. Awouafack, Haruhisa Kikuchi, Jean D.D. Tamokou, Jules R. Kuiate, Yoshiteru Oshima

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH ₂Cl ₂-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.

Original language	English
Pages (from-to)	596-599
Number of pages	4
Journal	Phytochemistry Letters
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/j.phytol.2012.06.002
Publication status	Published - 2012 Sept

Keywords

Antimicrobial activity
Asteraceae
Stigmastane derivatives
Vernoguinoside A
Vernonia guineensis

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2012.06.002

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title = "Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity",

abstract = "Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH 2Cl 2-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.",

keywords = "Antimicrobial activity, Asteraceae, Stigmastane derivatives, Vernoguinoside A, Vernonia guineensis",

author = "Donfack, {Arno R.N.} and Toyang, {Ngeh J.} and Wabo, {Hippolyte K.} and Pierre Tane and Awouafack, {Maurice D.} and Haruhisa Kikuchi and Tamokou, {Jean D.D.} and Kuiate, {Jules R.} and Yoshiteru Oshima",

note = "Funding Information: Financial support from the University of Dschang is gratefully acknowledged. H.K.W. is grateful to The Matsumae International Foundation (MIF) for a four-month fellowship at the Graduate School of Pharmaceutical Sciences, Tohoku University, Japan.",

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doi = "10.1016/j.phytol.2012.06.002",

language = "English",

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journal = "Phytochemistry Letters",

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AU - Donfack, Arno R.N.

AU - Toyang, Ngeh J.

AU - Wabo, Hippolyte K.

AU - Tane, Pierre

AU - Awouafack, Maurice D.

AU - Kikuchi, Haruhisa

AU - Tamokou, Jean D.D.

AU - Kuiate, Jules R.

AU - Oshima, Yoshiteru

N1 - Funding Information: Financial support from the University of Dschang is gratefully acknowledged. H.K.W. is grateful to The Matsumae International Foundation (MIF) for a four-month fellowship at the Graduate School of Pharmaceutical Sciences, Tohoku University, Japan.

PY - 2012/9

Y1 - 2012/9

N2 - Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH 2Cl 2-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.

AB - Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH 2Cl 2-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.

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KW - Stigmastane derivatives

KW - Vernoguinoside A

KW - Vernonia guineensis

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Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity

Abstract

Keywords

ASJC Scopus subject areas

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