Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin

Shu Xu; Hirokazu Arimoto

doi:10.1038/ja.2016.5

Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin

Shu Xu, Hirokazu Arimoto

LIF - Molecular and Chemical Life Science

Chinese Academy of Medical Sciences

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all-carbon macrocyclic skeleton. To the date, seven total syntheses, two formal total syntheses and a number of synthetic studies on this hot molecule have been reported. In this short review article, we mainly survey and comment on these efforts regarding the difficult macrocyclization strategies.

Original language	English
Pages (from-to)	203-212
Number of pages	10
Journal	Journal of Antibiotics
Volume	69
Issue number	4
DOIs	https://doi.org/10.1038/ja.2016.5
Publication status	Published - 2016 Apr 1

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10.1038/ja.2016.5

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abstract = "Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all-carbon macrocyclic skeleton. To the date, seven total syntheses, two formal total syntheses and a number of synthetic studies on this hot molecule have been reported. In this short review article, we mainly survey and comment on these efforts regarding the difficult macrocyclization strategies.",

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Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin

Abstract

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