TY - JOUR
T1 - Stress and survival after cancer
T2 - A prospective study of a Finnish population-based cohort
AU - Saito-Nakaya, Kumi
AU - Bidstrup, Pernille E.
AU - Nakaya, Naoki
AU - Frederiksen, Kirsten
AU - Dalton, Susanne O.
AU - Uchitomi, Yosuke
AU - Verkasalo, Pia
AU - Koskenvuo, Markku
AU - Pukkala, Eero
AU - Kaprio, Jaakko
AU - Johansen, Christoffer
N1 - Funding Information:
This study was carried out with support for a research fellowship from the Scandinavia–Japan Sasakawa Foundation, a postdoctoral fellowship for research abroad from the Uehara Memorial Foundation, the Promotion of Cancer Research (Japan) for the 3rd Term Comprehensive 10-year Strategy for Control and the Danish Cancer Society. The Finnish Twin Cohort study is supported by the Academy of Finland Centre of Excellence for Complex Disease Genetics. Markku Koskenvuo was supported by a grant for psychosocial cancer research from the Finnish Cancer Society. We wish to thank Visti B. Larsen of the Department of Psychosocial Cancer Research, Institute of Cancer Epidemiology, Danish Cancer Society, for statistical assistance.
PY - 2012/4
Y1 - 2012/4
N2 - Stress has been suggested to reduce survival after cancer, but the results of previous studies have been contradictory. We investigated the hypothesis in a national cohort of adults in Finland. Of those who completed the Stressful Life Events scale and the Stress of Daily Activities scale, 1470 and 1882, respectively, later had cancer and were included in the analysis, covering 23 years of follow-up between 1982 and 2004. In Cox regression analysis, the multivariate hazard ratio (HR) was 0.99 (95% confidence interval [CI], 0.96-1.01) for total number of life events and the HR for the life change score was 0.99 (95% CI, 0.95-1.03). Further, the HR was 0.92 (95% CI, 0.69-1.22) for severe daily stress. Overall, the results of the current study do not support the hypothesis that stress reduces cancer survival.
AB - Stress has been suggested to reduce survival after cancer, but the results of previous studies have been contradictory. We investigated the hypothesis in a national cohort of adults in Finland. Of those who completed the Stressful Life Events scale and the Stress of Daily Activities scale, 1470 and 1882, respectively, later had cancer and were included in the analysis, covering 23 years of follow-up between 1982 and 2004. In Cox regression analysis, the multivariate hazard ratio (HR) was 0.99 (95% confidence interval [CI], 0.96-1.01) for total number of life events and the HR for the life change score was 0.99 (95% CI, 0.95-1.03). Further, the HR was 0.92 (95% CI, 0.69-1.22) for severe daily stress. Overall, the results of the current study do not support the hypothesis that stress reduces cancer survival.
KW - Cancer
KW - Cohort study
KW - Finnish
KW - Stress
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84858794547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858794547&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2011.04.008
DO - 10.1016/j.canep.2011.04.008
M3 - Article
C2 - 22018951
AN - SCOPUS:84858794547
SN - 1877-7821
VL - 36
SP - 230
EP - 235
JO - Cancer Epidemiology
JF - Cancer Epidemiology
IS - 2
ER -
