TY - JOUR
T1 - Strong inhibitory effects of curcumin and its demethoxy analog on Escherichia coli ATP synthase F1 sector
AU - Sekiya, Mizuki
AU - Chiba, Eiko
AU - Satoh, Momoe
AU - Yamakoshi, Hiroyuki
AU - Iwabuchi, Yoshiharu
AU - Futai, Masamitsu
AU - Nakanishi-Matsui, Mayumi
N1 - Funding Information:
We are grateful to Ms. Eri Nishiyama and Mr. Ryosuke Hisasaka for their expert technical assistance. We are also grateful to Dr. Hiroyuki Shibata (Department of Clinical Oncology, Akita University) for his advise in the synthesis of curcumin analogs. This research was supported by a Grant-in-Aid for Young Scientists B (24790048) from the JSPS.
PY - 2014/9
Y1 - 2014/9
N2 - Curcumin, a dietary phytopolyphenol isolated from a perennial herb (Curcuma longa), is a well-known compound effective for bacterial infections and tumors, and also as an antioxidant. In this study, we report the inhibitory effects of curcumin and its analogs on the Escherichia coli ATP synthase F1 sector. A structure-activity relationship study indicated the importance of 4'-hydroxy groups and a β-diketone moiety for the inhibition. The 3'-demethoxy analog (DMC) inhibited F1 more strongly than curcumin did. Furthermore, these compounds inhibited E. coli growth through oxidative phosphorylation, consistent with their effects on ATPase activity. These results suggest that the two compounds affected bacterial growth through inhibition of ATP synthase. Derivatives including bis(arylmethylidene)acetones (C5 curcuminoids) exhibited only weak activity toward ATPase and bacterial growth.
AB - Curcumin, a dietary phytopolyphenol isolated from a perennial herb (Curcuma longa), is a well-known compound effective for bacterial infections and tumors, and also as an antioxidant. In this study, we report the inhibitory effects of curcumin and its analogs on the Escherichia coli ATP synthase F1 sector. A structure-activity relationship study indicated the importance of 4'-hydroxy groups and a β-diketone moiety for the inhibition. The 3'-demethoxy analog (DMC) inhibited F1 more strongly than curcumin did. Furthermore, these compounds inhibited E. coli growth through oxidative phosphorylation, consistent with their effects on ATPase activity. These results suggest that the two compounds affected bacterial growth through inhibition of ATP synthase. Derivatives including bis(arylmethylidene)acetones (C5 curcuminoids) exhibited only weak activity toward ATPase and bacterial growth.
KW - ATP synthase
KW - Curcumin
KW - F-ATPase
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U2 - 10.1016/j.ijbiomac.2014.06.055
DO - 10.1016/j.ijbiomac.2014.06.055
M3 - Article
C2 - 25010476
AN - SCOPUS:84904470751
SN - 0141-8130
VL - 70
SP - 241
EP - 245
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -