TY - JOUR
T1 - Stronger inhibition of gastric acid secretion by lafutidine, a novel H2 receptor antagonist, than by the proton pump inhibitor lansoprazole
AU - Yamagishi, Hatsushi
AU - Koike, Tomoyuki
AU - Ohara, Shuichi
AU - Horii, Toru
AU - Kikuchi, Ryousuke
AU - Kobayashi, Shigeyuki
AU - Abe, Yasuhiko
AU - Iijima, Katsunori
AU - Imatani, Akira
AU - Suzuki, Kaori
AU - Hishinuma, Takanori
AU - Goto, Junichi
AU - Shimosegawa, Tooru
PY - 2008/4/21
Y1 - 2008/4/21
N2 - Aim: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2, receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. Methods: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. Results: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. Conclusion: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidine than by LPZ.
AB - Aim: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2, receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. Methods: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. Results: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. Conclusion: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidine than by LPZ.
KW - Antisecretory activity
KW - H receptor antagonists
KW - Lafutidine
KW - Lansoprazole
KW - Proton pump inhibitors
UR - https://www.scopus.com/pages/publications/45849144006
UR - https://www.scopus.com/pages/publications/45849144006#tab=citedBy
U2 - 10.3748/wjg.14.2406
DO - 10.3748/wjg.14.2406
M3 - Article
C2 - 18416470
AN - SCOPUS:45849144006
SN - 1007-9327
VL - 14
SP - 2406
EP - 2410
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 15
ER -