Structural view of cadherin-mediated cell-cell adhesion

J. R. Alattia, H. Kurokawa, M. Ikura

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Following the multiplication of biochemical, biophysical and structural studies describing cadherin molecules and their interactions, several ideas have emerged to explain the mechanisms of cadherin-mediated cell adhesion. Although different models were proposed for cadherin interactions, a consensus has come forth considering lateral dimerization of cadherins as being a central component of the cell-cell adhesion process. This review summarizes the recent development in structural studies of cadherins.

Original languageEnglish
Pages (from-to)359-367
Number of pages9
JournalCellular and Molecular Life Sciences
Issue number3
Publication statusPublished - 1999


  • Cadherin
  • Calcium
  • Cell adhesion
  • Dimerization
  • Protein interaction


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