Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression

Teigo Asai; Takashi Yamamoto; Naoki Shirata; Tohru Taniguchi; Kenji Monde; Isao Fujii; Katsuya Gomi; Yoshiteru Oshima

doi:10.1021/ol401386w

Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression

Teigo Asai, Takashi Yamamoto, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Isao Fujii, Katsuya Gomi, Yoshiteru Oshima

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Epigenetic manipulation of gene expression in Chaetomium indicum using a HDAC inhibitor led to the isolation of structurally diverse chaetophenols, and 3, 4 and 5 bear unprecedented polycyclic skeletons. The expression of two silent genes (pksCH-1 and pksCH-2) for nonreducing PKSs involved in chaetophenol biosynthesis was associated with an increase of histone acetylation level. The heterologous gene expression study in Aspergillus oryzae revealed pksCH-2 to be the NR-PKS gene for 8.

Original language	English
Pages (from-to)	3346-3349
Number of pages	4
Journal	Organic letters
Volume	15
Issue number	13
DOIs	https://doi.org/10.1021/ol401386w
Publication status	Published - 2013 Jul 5

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol401386w

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title = "Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression",

abstract = "Epigenetic manipulation of gene expression in Chaetomium indicum using a HDAC inhibitor led to the isolation of structurally diverse chaetophenols, and 3, 4 and 5 bear unprecedented polycyclic skeletons. The expression of two silent genes (pksCH-1 and pksCH-2) for nonreducing PKSs involved in chaetophenol biosynthesis was associated with an increase of histone acetylation level. The heterologous gene expression study in Aspergillus oryzae revealed pksCH-2 to be the NR-PKS gene for 8.",

author = "Teigo Asai and Takashi Yamamoto and Naoki Shirata and Tohru Taniguchi and Kenji Monde and Isao Fujii and Katsuya Gomi and Yoshiteru Oshima",

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journal = "Organic Letters",

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TY - JOUR

T1 - Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression

AU - Asai, Teigo

AU - Yamamoto, Takashi

AU - Shirata, Naoki

AU - Taniguchi, Tohru

AU - Monde, Kenji

AU - Fujii, Isao

AU - Gomi, Katsuya

AU - Oshima, Yoshiteru

PY - 2013/7/5

Y1 - 2013/7/5

N2 - Epigenetic manipulation of gene expression in Chaetomium indicum using a HDAC inhibitor led to the isolation of structurally diverse chaetophenols, and 3, 4 and 5 bear unprecedented polycyclic skeletons. The expression of two silent genes (pksCH-1 and pksCH-2) for nonreducing PKSs involved in chaetophenol biosynthesis was associated with an increase of histone acetylation level. The heterologous gene expression study in Aspergillus oryzae revealed pksCH-2 to be the NR-PKS gene for 8.

AB - Epigenetic manipulation of gene expression in Chaetomium indicum using a HDAC inhibitor led to the isolation of structurally diverse chaetophenols, and 3, 4 and 5 bear unprecedented polycyclic skeletons. The expression of two silent genes (pksCH-1 and pksCH-2) for nonreducing PKSs involved in chaetophenol biosynthesis was associated with an increase of histone acetylation level. The heterologous gene expression study in Aspergillus oryzae revealed pksCH-2 to be the NR-PKS gene for 8.

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AN - SCOPUS:84880028198

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VL - 15

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EP - 3349

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -

Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression

Abstract

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