TY - JOUR
T1 - Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells
AU - Ishikawa, Makoto
AU - Sawada, Yu
AU - Yoshitomi, Takeshi
N1 - Funding Information:
This work was supported in part by JSPS KAKENHI Grant No. 24592666 to M.I.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions.
AB - The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions.
KW - Age-related macular degeneration
KW - Growth factors
KW - Inherited retinal degenerative disorders
KW - Interphotoreceptor matrix
KW - Interphotoreceptor retinoid binding protein
KW - Photoreceptor cell
KW - Proteoglycans
KW - Retina
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U2 - 10.1016/j.exer.2015.02.017
DO - 10.1016/j.exer.2015.02.017
M3 - Article
C2 - 25819450
AN - SCOPUS:84925456027
SN - 0014-4835
VL - 133
SP - 3
EP - 18
JO - Experimental Eye Research
JF - Experimental Eye Research
ER -