Structure of the gene encoding rat neutrophil chemo-attractant gro

Konishi Kiyoshi; Takata Yoshimi; Yamamoto Masayuki; Yomogida Kentaro; Watanabe Kazuyoshi; Tsurufuji Susumu; Fujioka Motoji

doi:10.1016/0378-1119(93)90382-D

Structure of the gene encoding rat neutrophil chemo-attractant gro

Konishi Kiyoshi, Takata Yoshimi, Yamamoto Masayuki, Yomogida Kentaro, Watanabe Kazuyoshi, Tsurufuji Susumu, Fujioka Motoji

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A cloned rat gro gene encoding the neutrophil chemo-attractant Gro was isolated from a λCharon4A rat genomic library, and the nucleotide (nt) sequence of a 2500-bp fragment encompassing the coding region and 3'- and 5'-flanking regions was determined. The gene consisted of four exons separated by three introns. The transcription start point was determined by primer-extension analysis and found to be a G located 72 nt upstream from the start codon. The 5'- flanking region of the gene contained a 'TATA'-like structure and an NF-κB-binding sequence.

Original language	English
Pages (from-to)	285-286
Number of pages	2
Journal	Gene
Volume	126
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(93)90382-D
Publication status	Published - 1993 Apr 30

Keywords

Cytokine
interleukin-8 family
transcription start point

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(93)90382-D

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title = "Structure of the gene encoding rat neutrophil chemo-attractant gro",

abstract = "A cloned rat gro gene encoding the neutrophil chemo-attractant Gro was isolated from a λCharon4A rat genomic library, and the nucleotide (nt) sequence of a 2500-bp fragment encompassing the coding region and 3'- and 5'-flanking regions was determined. The gene consisted of four exons separated by three introns. The transcription start point was determined by primer-extension analysis and found to be a G located 72 nt upstream from the start codon. The 5'- flanking region of the gene contained a 'TATA'-like structure and an NF-κB-binding sequence.",

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AU - Kiyoshi, Konishi

AU - Yoshimi, Takata

AU - Masayuki, Yamamoto

AU - Kentaro, Yomogida

AU - Kazuyoshi, Watanabe

AU - Susumu, Tsurufuji

AU - Motoji, Fujioka

PY - 1993/4/30

Y1 - 1993/4/30

N2 - A cloned rat gro gene encoding the neutrophil chemo-attractant Gro was isolated from a λCharon4A rat genomic library, and the nucleotide (nt) sequence of a 2500-bp fragment encompassing the coding region and 3'- and 5'-flanking regions was determined. The gene consisted of four exons separated by three introns. The transcription start point was determined by primer-extension analysis and found to be a G located 72 nt upstream from the start codon. The 5'- flanking region of the gene contained a 'TATA'-like structure and an NF-κB-binding sequence.

AB - A cloned rat gro gene encoding the neutrophil chemo-attractant Gro was isolated from a λCharon4A rat genomic library, and the nucleotide (nt) sequence of a 2500-bp fragment encompassing the coding region and 3'- and 5'-flanking regions was determined. The gene consisted of four exons separated by three introns. The transcription start point was determined by primer-extension analysis and found to be a G located 72 nt upstream from the start codon. The 5'- flanking region of the gene contained a 'TATA'-like structure and an NF-κB-binding sequence.

KW - Cytokine

KW - interleukin-8 family

KW - transcription start point

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Structure of the gene encoding rat neutrophil chemo-attractant gro

Abstract

Keywords

ASJC Scopus subject areas

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