Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses

Haruhisa Kikuchi; Masato Isobe; Mizuki Sekiya; Yuko Abe; Tsuyoshi Hoshikawa; Kazunori Ueda; Shoichiro Kurata; Yasuhiro Katou; Yoshiteru Oshima

doi:10.1021/ol2018449

Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses

Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima

PHA - Life and Pharmaceutical Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.

Original language	English
Pages (from-to)	4624-4627
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	17
DOIs	https://doi.org/10.1021/ol2018449
Publication status	Published - 2011 Sept 2

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10.1021/ol2018449

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AU - Kikuchi, Haruhisa

AU - Isobe, Masato

AU - Sekiya, Mizuki

AU - Abe, Yuko

AU - Hoshikawa, Tsuyoshi

AU - Ueda, Kazunori

AU - Kurata, Shoichiro

AU - Katou, Yasuhiro

AU - Oshima, Yoshiteru

PY - 2011/9/2

Y1 - 2011/9/2

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AB - Innate immunity is the front line of self-defense against microbial infection. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a novel dimeric chromanone, gonytolide A, as an innate immune promoter from the fungus Gonytrichum sp. along with gonytolides B and C. Gonytolide A also increased TNF-α-stimulated production of IL-8 in human umbilical vein endothelial cells.

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Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses

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