TY - JOUR
T1 - Studies on combination of antibiotics (III)
AU - Aonuma, Seiichi
AU - Onuma, Kikuo
AU - Watanabe, Akira
AU - Sasaki, Masako
AU - Oizumi, Kohtaro
AU - Konno, Kiyoshi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1982
Y1 - 1982
N2 - In vitro combined activity of piperacillin (PIPC) and dibekacin (DKB) against clinical isolates of S. aureus, K. pneumoniae, E. coli, S. marcescens, E. cloacae was investigated by use of Dynatech MIC 2000. Excellent combined effects were observed against all of tested species. Synergism (FIC index <0. was demonstrated in 40%, 70%, 36.8%, 55%, 47.1%, in above mentioned species respectively. Bactericidal activity against K. pneumoniae PCI 602 was enhanced by combination of PIPC and DKB. When bacilli were treated for 4 hours with PIPC (1/8 MIC) plus DKB (1/2 MIC), the viable cell count decreased markedly and the colony-forming-unit was found to be 1/100000 of the initial inoculum.
AB - In vitro combined activity of piperacillin (PIPC) and dibekacin (DKB) against clinical isolates of S. aureus, K. pneumoniae, E. coli, S. marcescens, E. cloacae was investigated by use of Dynatech MIC 2000. Excellent combined effects were observed against all of tested species. Synergism (FIC index <0. was demonstrated in 40%, 70%, 36.8%, 55%, 47.1%, in above mentioned species respectively. Bactericidal activity against K. pneumoniae PCI 602 was enhanced by combination of PIPC and DKB. When bacilli were treated for 4 hours with PIPC (1/8 MIC) plus DKB (1/2 MIC), the viable cell count decreased markedly and the colony-forming-unit was found to be 1/100000 of the initial inoculum.
UR - http://www.scopus.com/inward/record.url?scp=0020459350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020459350&partnerID=8YFLogxK
U2 - 10.11250/chemotherapy1953.30.776
DO - 10.11250/chemotherapy1953.30.776
M3 - Article
AN - SCOPUS:0020459350
SN - 0009-3165
VL - 30
SP - 776
EP - 780
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
IS - 7
ER -
