TY - JOUR
T1 - Studies on multiple-resistant staphylococcus aureus. (V). In vitro combined effect of cefuzonam plus minocycline against methicillin-resistant staphylococcus aureus (MRSA)
AU - Watanabe, Akira
AU - Ohizumi, Kohtaro
AU - Aonuma, Seiichi
AU - Ono, Reiko
AU - Honda, Yoshihiro
AU - Tokue, Yutaka
AU - Kitamura, Naoto
AU - Shoji, Satoru
AU - Konno, Kiyoshi
PY - 1989/1/1
Y1 - 1989/1/1
N2 - The in vitro combined effect of cefuzonam (CZON) plus minocycline (MINO) against 403 strains of Staphylococcus aureus (152 MRSA and 251 MSSA strains) isolated in the Tohoku district of Japan in 1987, was examined by a checkerboard microbroth dilution method using the Dynatech MIC-2000. The mean FIC (fractional inhibitory concentration) index of this combination for all 403 strains of S. aureus was 0.652, being 0429 for MRS A, and 0.764 for MSSA. This combination was more effective against highly-resistant MRSA strains (MIC>25μg/ml), as revealed by the mean FIC index of 0.405, than against moderately-resistant MRSA strains (MIC=12.5 and 25 μg/ml), whose mean FIC index was 0.485. It was also more effective against cefuzonam-resistant than against cefuzonam-sensitive MRSA strains: the mean FIC index being 0.388 for those strains whose MIC exceeded 6.25 μg/ml; 0.520 for those whose MIC was 6.25, 3.13 or 1.56μg/ml; and 0.625 for those whose MIC was below 1.56μg/ml. On the other hand, when the MIC of minocycline against MRSA was high, the mean FIC index of the combination was not markedly decreased by the addition of cefuzonam. Based on our results, we conclude that minocycline made a more significant contribution to this combination Than did cefuzonam.
AB - The in vitro combined effect of cefuzonam (CZON) plus minocycline (MINO) against 403 strains of Staphylococcus aureus (152 MRSA and 251 MSSA strains) isolated in the Tohoku district of Japan in 1987, was examined by a checkerboard microbroth dilution method using the Dynatech MIC-2000. The mean FIC (fractional inhibitory concentration) index of this combination for all 403 strains of S. aureus was 0.652, being 0429 for MRS A, and 0.764 for MSSA. This combination was more effective against highly-resistant MRSA strains (MIC>25μg/ml), as revealed by the mean FIC index of 0.405, than against moderately-resistant MRSA strains (MIC=12.5 and 25 μg/ml), whose mean FIC index was 0.485. It was also more effective against cefuzonam-resistant than against cefuzonam-sensitive MRSA strains: the mean FIC index being 0.388 for those strains whose MIC exceeded 6.25 μg/ml; 0.520 for those whose MIC was 6.25, 3.13 or 1.56μg/ml; and 0.625 for those whose MIC was below 1.56μg/ml. On the other hand, when the MIC of minocycline against MRSA was high, the mean FIC index of the combination was not markedly decreased by the addition of cefuzonam. Based on our results, we conclude that minocycline made a more significant contribution to this combination Than did cefuzonam.
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U2 - 10.11250/chemotherapy1953.37.131
DO - 10.11250/chemotherapy1953.37.131
M3 - Article
AN - SCOPUS:85004390326
SN - 0009-3165
VL - 37
SP - 131
EP - 136
JO - CHEMOTHERAPY
JF - CHEMOTHERAPY
IS - 2
ER -
