Studies toward the enantioselective synthesis of neurymenolide A: Construction of the macrocyclic core via Claisen rearrangement

Masahiro Masuda, Natsuki Sakurai, Yusuke Ogura, Tetsuji Murase, Tsuneomi Kawasaki, Shohei Aiba, Naoki Mori, Hidenori Watanabe, Hirosato Takikawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Neurymenolides, α-pyrone macrolides isolated from the Fijian red alga Neurymenia fraxinifolia, are anti-methicillin-resistant Staphylococcus aureus and anti-vancomycin-resistant Enterococcus faecium compounds. In this study, the macrocyclic core of neurymenolide A was constructed in an enantioselective manner by employing Claisen rearrangement as the key step.

Original languageEnglish
Article number151825
JournalTetrahedron Letters
Volume61
Issue number18
DOIs
Publication statusPublished - 2020 Apr 30

Keywords

  • Claisen rearrangement
  • Macrolides
  • Neurymenolides
  • α-Pyrone

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