Studies toward the total synthesis of gambieric acids: Stereocontrolled synthesis of a DEFG-ring model compound

Haruhiko Fuwa; Sayaka Noji; Makoto Sasaki

doi:10.1021/jo1008146

Studies toward the total synthesis of gambieric acids: Stereocontrolled synthesis of a DEFG-ring model compound

Haruhiko Fuwa, Sayaka Noji, Makoto Sasaki

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

(Figure presented) A stereocontrolled convergent synthesis of a DEFG-ring model compound of gambieric acids, highly potent antifungal marine polycyclic ether natural products, has been achieved based on Suzuki- Miyaura coupling. Conformational analysis of the model compound revealed that the nine-membered F-ring exists exclusively as a single stable conformer, as opposed to that of ciguatoxins.

Original language	English
Pages (from-to)	5072-5082
Number of pages	11
Journal	Journal of Organic Chemistry
Volume	75
Issue number	15
DOIs	https://doi.org/10.1021/jo1008146
Publication status	Published - 2010 Aug 6

ASJC Scopus subject areas

Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jo1008146

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abstract = "(Figure presented) A stereocontrolled convergent synthesis of a DEFG-ring model compound of gambieric acids, highly potent antifungal marine polycyclic ether natural products, has been achieved based on Suzuki- Miyaura coupling. Conformational analysis of the model compound revealed that the nine-membered F-ring exists exclusively as a single stable conformer, as opposed to that of ciguatoxins.",

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Studies toward the total synthesis of gambieric acids: Stereocontrolled synthesis of a DEFG-ring model compound

Abstract

ASJC Scopus subject areas

UN SDGs

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