Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica

Tetsuya Akaishi; Kimihiko Kaneko; Noriko Himori; Takayuki Takeshita; Toshiyuki Takahashi; Toru Nakazawa; Masashi Aoki; Ichiro Nakashima

doi:10.1016/j.jneuroim.2017.10.001

Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica

Tetsuya Akaishi, Kimihiko Kaneko, Noriko Himori, Takayuki Takeshita, Toshiyuki Takahashi, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON. Long-term follow up of OCT is recommended even in the unaffected side in MS-ON and AQP4-ON.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	313
DOIs	https://doi.org/10.1016/j.jneuroim.2017.10.001
Publication status	Published - 2017 Dec 15

Keywords

Multiple sclerosis
Myelin oligodendrocyte glycoprotein
Neuromyelitis optica
Optic coherence tomography
Unaffected side

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2017.10.001

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title = "Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica",

abstract = "We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON. Long-term follow up of OCT is recommended even in the unaffected side in MS-ON and AQP4-ON.",

keywords = "Multiple sclerosis, Myelin oligodendrocyte glycoprotein, Neuromyelitis optica, Optic coherence tomography, Unaffected side",

author = "Tetsuya Akaishi and Kimihiko Kaneko and Noriko Himori and Takayuki Takeshita and Toshiyuki Takahashi and Toru Nakazawa and Masashi Aoki and Ichiro Nakashima",

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T1 - Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica

AU - Akaishi, Tetsuya

AU - Kaneko, Kimihiko

AU - Himori, Noriko

AU - Takeshita, Takayuki

AU - Takahashi, Toshiyuki

AU - Nakazawa, Toru

AU - Aoki, Masashi

AU - Nakashima, Ichiro

PY - 2017/12/15

Y1 - 2017/12/15

N2 - We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON. Long-term follow up of OCT is recommended even in the unaffected side in MS-ON and AQP4-ON.

AB - We compared the retinal thickness in the unaffected eyes among the following subtypes of unilateral optic neuritis (ON): multiple sclerosis (MS-ON), neuromyelitis optica spectrum disorder with anti-AQP4 autoantibody (AQP4-ON), patients with serum anti-MOG antibody (MOG-ON), and idiopathic ON. In the chronic phase, macular GCC and circum-papillary RNFL in the unaffected eyes were both atrophied in MS-ON and AQP4-ON, but were not atrophied in the others. Titers of anti-AQP4-Ab was suggested to be associated with such latent neurodegenerative process in AQP4-ON. Long-term follow up of OCT is recommended even in the unaffected side in MS-ON and AQP4-ON.

KW - Multiple sclerosis

KW - Myelin oligodendrocyte glycoprotein

KW - Neuromyelitis optica

KW - Optic coherence tomography

KW - Unaffected side

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DO - 10.1016/j.jneuroim.2017.10.001

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SN - 0165-5728

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JO - Advances in Neuroimmunology

JF - Advances in Neuroimmunology

ER -

Subclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica

Abstract

Keywords

ASJC Scopus subject areas

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