TY - JOUR
T1 - Subgroup differences in ‘brain-type’ transferrin and a-synuclein in Parkinson’s disease and multiple system atrophy
AU - Yoshihara, Akioh
AU - Fukatsu, Masahiko
AU - Hoshi, Kyoka
AU - Ito, Hiromi
AU - Nollet, Kenneth
AU - Yamaguchi, Yoshiki
AU - Ishii, Ryotaro
AU - Tokuda, Takahiko
AU - Miyajima, Masakazu
AU - Arai, Hajime
AU - Kato, Takeo
AU - Furukawa, Katsutoshi
AU - Arai, Hiroyuki
AU - Kikuchi, Akio
AU - Takeda, Atsushi
AU - Ugawa, Yoshikazu
AU - Hashimoto, Yasuhiro
N1 - Funding Information:
This work was partly supported by the New Energy and Industrial Technology Development Organization (MG project); the Ministry of Health, Labor, and Welfare of Japan (2014-Nanchi-Ippan-052); the Japan Science and Technology Agency (AS221Z00232F, AS231Z01053, 241FT0255 and 149); the Ministry of Education, Culture, Sports, Science and Technology of Japan (a Grant-in-Aid for Scientific Research on Innovative Areas, 23110002 [Deciphering sugar chain-based signals regulating integrative neuronal functions] and a Grant-in-Aid for Scientific Research, 23590367).
Publisher Copyright:
© The Authors 2016.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Two transferrin (Tf) glycan-isoforms were previously found in cerebrospinal fluid (CSF); one appears to be derived from serum (Tf-2) and the other from choroid plexus, a CSF-producing tissue (Tf-1). To analyse metabolic differences associated with the two isoforms, their ratio (Tf-2/Tf-1) was defined as the Tf index. Here we report that Tf indices of patients with tauopathies including Alzheimer’s disease (2.29 + 0.64) were similar to those of neurological controls (2.07 + 0.87) (P = 0.147). In contrast, Tf indices with Parkinson’s disease (PD, 3.38 ± 1.87) and multiple system atrophy (MSA, 3.15 ± 1.72) were higher than those of the controls (2.07 ± 0.87), the P-values being 5 0.001 and 0.024, respectively. Tf indices of PD and MSA did not appear to be normally distributed. Indeed, detrended normal Quantile-Quantile plot analysis revealed the presence of an independent subgroup showing higher Tf indices in PD and MSA. The subgroup of PD showed higher levels of CSF a-synuclein (38.3 ± 17.8 ng/ml) than the rest (25.3 ± 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA) includes two subgroups, which show different metabolism of CSF transferrin and a-synuclein.
AB - Two transferrin (Tf) glycan-isoforms were previously found in cerebrospinal fluid (CSF); one appears to be derived from serum (Tf-2) and the other from choroid plexus, a CSF-producing tissue (Tf-1). To analyse metabolic differences associated with the two isoforms, their ratio (Tf-2/Tf-1) was defined as the Tf index. Here we report that Tf indices of patients with tauopathies including Alzheimer’s disease (2.29 + 0.64) were similar to those of neurological controls (2.07 + 0.87) (P = 0.147). In contrast, Tf indices with Parkinson’s disease (PD, 3.38 ± 1.87) and multiple system atrophy (MSA, 3.15 ± 1.72) were higher than those of the controls (2.07 ± 0.87), the P-values being 5 0.001 and 0.024, respectively. Tf indices of PD and MSA did not appear to be normally distributed. Indeed, detrended normal Quantile-Quantile plot analysis revealed the presence of an independent subgroup showing higher Tf indices in PD and MSA. The subgroup of PD showed higher levels of CSF a-synuclein (38.3 ± 17.8 ng/ml) than the rest (25.3 ± 11.3 ng/ml, P = 0.012). These results suggest that PD (and MSA) includes two subgroups, which show different metabolism of CSF transferrin and a-synuclein.
KW - α-synuclein/cerebrospinal fluid/Parkinson’s disease/synucleinopathy/transferring
UR - http://www.scopus.com/inward/record.url?scp=85021851144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021851144&partnerID=8YFLogxK
U2 - 10.1093/jb/mvw015
DO - 10.1093/jb/mvw015
M3 - Article
C2 - 26970280
AN - SCOPUS:85021851144
SN - 0021-924X
VL - 160
SP - 87
EP - 91
JO - Journal of Biochemistry
JF - Journal of Biochemistry
IS - 2
ER -