TY - JOUR
T1 - Substitution of Lysine for Arginine in the N-Terminal 217th Amino Acid Residue of the hγII of Staphylococcal γ-Hemolysin Lowers the Activity of the Toxin
AU - Sudo, Keiichi
AU - Choorit, Wanna
AU - Asami, Ikuno
AU - Kaneko, Jun
AU - Muramoto, Koji
AU - Kamio, Yoshiyuki
N1 - Funding Information:
Acknowledgments. This work was supported in part by grants from the Ministry of Education, Science, and Culture of Japan (05304028 and 06670280); The Naito Foundation; the Yamada Science Foundation; and the Foundation of the Japanisch-Deutsches Kulturinstitut.
PY - 1995
Y1 - 1995
N2 - The staphyloccocal toxin γ-hemolysin consists of two protein components, LukF and HγII. Staphylococcus aureus P83 was found to have five components, LukF, LukF-PV, LukM, LukS, and HγII for leukocidin orγ-hemolysin. HγII of S. aureus P83 was demonstrated to be a naturally-occurring analogous molecule of HγII [HγII(P83)], in which the 217th arginine residue was replaced by lysine. The HγII(P83) showed about 50% of the hemolytic activity of normal HγII in the presence of LukF.
AB - The staphyloccocal toxin γ-hemolysin consists of two protein components, LukF and HγII. Staphylococcus aureus P83 was found to have five components, LukF, LukF-PV, LukM, LukS, and HγII for leukocidin orγ-hemolysin. HγII of S. aureus P83 was demonstrated to be a naturally-occurring analogous molecule of HγII [HγII(P83)], in which the 217th arginine residue was replaced by lysine. The HγII(P83) showed about 50% of the hemolytic activity of normal HγII in the presence of LukF.
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U2 - 10.1271/bbb.59.1786
DO - 10.1271/bbb.59.1786
M3 - Article
C2 - 8520122
AN - SCOPUS:0029367525
SN - 0916-8451
VL - 59
SP - 1786
EP - 1789
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 9
ER -